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Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

Abstract

Enhancers function as DNA logic gates and may control specialized functions of billions of neurons. Here we show a tailored program of noncoding genome elements active in situ in physiologically distinct dopamine neurons of the human brain. We found 71,022 transcribed noncoding elements, many of which were consistent with active enhancers and with regulatory mechanisms in zebrafish and mouse brains. Genetic variants associated with schizophrenia, addiction, and Parkinson's disease were enriched in these elements. Expression quantitative trait locus analysis revealed that Parkinson's disease-associated variants on chromosome 17q21 cis-regulate the expression of an enhancer RNA in dopamine neurons. This study shows that enhancers in dopamine neurons link genetic variation to neuropsychiatric traits.

Type Journal
ISBN 1546-1726 (Electronic) 1097-6256 (Linking)
Authors Dong, X.; Liao, Z.; Gritsch, D.; Hadzhiev, Y.; Bai, Y.; Locascio, J. J.; Guennewig, B.; Liu, G.; Blauwendraat, C.; Wang, T.; Adler, C. H.; Hedreen, J. C.; Faull, R. L. M.; Frosch, M. P.; Nelson, P. T.; Rizzu, P.; Cooper, A. A.; Heutink, P.; Beach, T. G.; Mattick, J. S.; Muller, F.; Scherzer, C. R.
Responsible Garvan Author A/Prof Antony Cooper
Publisher Name NATURE NEUROSCIENCE
Published Date 2018-09-17
Published Volume 21
Published Issue 10
Published Pages 1482-1492
Status Published in-print
DOI 10.1038/s41593-018-0223-0
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/30224808