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The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control

Abstract

The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.

Type Journal
ISBN 1538-3008 (Electronic) 0091-6331 (Linking)
Authors Hodson, N.; Philp, A.
Responsible Garvan Author Dr Andy Philp
Publisher Name EXERCISE AND SPORT SCIENCES REVIEWS
Published Date 2018-01-07
Status Published in-print
DOI 10.1249/JES.0000000000000173
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/30334852
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/14760