The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.
|ISBN||1538-3008 (Electronic) 0091-6331 (Linking)|
|Authors||Hodson, N.; Philp, A.|
|Responsible Garvan Author|
|Publisher Name||EXERCISE AND SPORT SCIENCES REVIEWS|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/30334852|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/14760|