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Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses


Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4(+) and CD8(+) T cells. Patients with clinically significant immunodeficiency and immune dysregulation resulting from loss-of-function or gain-of-function mutations in STAT3 have been described. These individuals provide insight into the critical role of this transcription factor in the regulation of immune responses and the balance between effective immune protection and autoimmunity.

Type Journal
ISBN 1664-3224 (Print) 1664-3224 (Linking)
Authors Deenick, E. K.; Pelham, S. J.; Kane, A.; Ma, C. S.
Responsible Garvan Author A/Prof Cindy Ma
Publisher Name Frontiers in Immunology
Published Date 2018-02-07
Published Volume 9
Published Pages 168
Status Always Electronic
DOI 10.3389/fimmu.2018.00168
URL link to publisher's version