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Vitamin D and muscle

Abstract

Vitamin D is increasingly recognised to play an important role in normal muscle function. Low vitamin D status is associated with an increased risk of falls and proximal weakness. Since vitamin D deficiency is very common, and the signs are non-specific, it is important to maintain a high index of suspicion of vitamin D deficiency in patients with muscle pain and weakness, and it is simple to measure serum 25(OH) vitamin D. Therapy is cheap, safe and effective, but sometimes a larger dose may be needed, and, as shown in our case report, willingness of people to pay for an over the counter medication can be an issue. Following a striking case report that demonstrates muscle defects in severe vitamin D deficiency, we discuss clinical studies examining specific effects of vitamin D on physical performance, muscle strength and falls. Finally, we present an overview of molecular mechanisms that explain vitamin D's biological effects on muscle.

Type Journal
ISBN 2352-1872 (Print) 2352-1872 (Linking)
Authors Gunton, J. E.; Girgis, C. M.
Responsible Garvan Author Prof Jenny Gunton
Publisher Name BONE
Published Date 2018-06-01
Published Volume 8
Published Pages 163-167
Status Always Electronic
DOI 10.1016/j.bonr.2018.04.004
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/29963601