Decorin, a growth hormone-regulated protein in humans
CONTEXT: Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy. Whether GH and testosterone regulate decorin in humans is not known. OBJECTIVE: To determine whether decorin is stimulated by GH and testosterone. DESIGN: Randomized, placebo-controlled, double-blind study. PARTICIPANTS AND INTERVENTION: 96 recreationally trained athletes (63 men, 33 women) received 8 weeks of treatment followed by a 6-week washout period. Men received placebo, GH (2 mg/day), testosterone (250 mg/week) or combination. Women received either placebo or GH (2 mg/day). MAIN OUTCOME MEASURE: Serum decorin concentration. RESULTS: GH treatment significantly increased mean serum decorin concentration by 12.7 +/- 4.2%; P < 0.01. There was a gender difference in the decorin response to GH, with greater increase in men than in women ( 16.5 +/- 5.3%; P < 0.05 compared to 9.4 +/- 6.5%; P = 0.16). Testosterone did not significantly change serum decorin. Combined GH and testosterone treatment increased mean decorin concentration by 19.5 +/- 3.7% (P < 0.05), a change not significantly different from GH alone. CONCLUSION: GH significantly increases circulating decorin, an effect greater in men than in women. Decorin is not affected by testosterone. We conclude that GH positively regulates decorin in humans in a gender-dimorphic manner.
|ISBN||1479-683X (Electronic) 0804-4643 (Linking)|
|Authors||Bahl, N.; Stone, G.; McLean, M.; Ho, K. K. Y.; Birzniece, V.|
|Responsible Garvan Author|
|Publisher Name||EUROPEAN JOURNAL OF ENDOCRINOLOGY|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/29138241|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/14797|