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Decorin, a growth hormone-regulated protein in humans


CONTEXT: Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy. Whether GH and testosterone regulate decorin in humans is not known. OBJECTIVE: To determine whether decorin is stimulated by GH and testosterone. DESIGN: Randomized, placebo-controlled, double-blind study. PARTICIPANTS AND INTERVENTION: 96 recreationally trained athletes (63 men, 33 women) received 8 weeks of treatment followed by a 6-week washout period. Men received placebo, GH (2 mg/day), testosterone (250 mg/week) or combination. Women received either placebo or GH (2 mg/day). MAIN OUTCOME MEASURE: Serum decorin concentration. RESULTS: GH treatment significantly increased mean serum decorin concentration by 12.7 +/- 4.2%; P < 0.01. There was a gender difference in the decorin response to GH, with greater increase in men than in women ( 16.5 +/- 5.3%; P < 0.05 compared to 9.4 +/- 6.5%; P = 0.16). Testosterone did not significantly change serum decorin. Combined GH and testosterone treatment increased mean decorin concentration by 19.5 +/- 3.7% (P < 0.05), a change not significantly different from GH alone. CONCLUSION: GH significantly increases circulating decorin, an effect greater in men than in women. Decorin is not affected by testosterone. We conclude that GH positively regulates decorin in humans in a gender-dimorphic manner.

Type Journal
ISBN 1479-683X (Electronic) 0804-4643 (Linking)
Authors Bahl, N.; Stone, G.; McLean, M.; Ho, K. K. Y.; Birzniece, V.
Responsible Garvan Author (missing name)
Published Date 2018-02-01
Published Volume 178
Published Issue 2
Published Pages 147-154
Status Published in-print
DOI 10.1530/EJE-17-0844
URL link to publisher's version
OpenAccess link to author's accepted manuscript version