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Recent advances in understanding the complexities of metastasis


Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-autonomous program but as a multifaceted and complex series of events, which is influenced by the intrinsic cellular mutational burden of cancer cells and the numerous bidirectional interactions between malignant and non-malignant cells and fine-tuned by the various extrinsic cues of the extracellular matrix. In cancer biology, metastasis as a process is one of the most technically challenging aspects of cancer biology to study. As a result, new platforms and technologies are continually being developed to better understand this process. In this review, we discuss some of the recent advances in metastasis and how the information gleaned is re-shaping our understanding of metastatic dissemination.

Type Journal
ISBN 2046-1402 (Electronic) 2046-1402 (Linking)
Authors Chitty, J. L.; Filipe, E. C.; Lucas, M. C.; Herrmann, D.; Cox, T. R.; Timpson, P.
Responsible Garvan Author Prof Paul Timpson
Publisher Name Methods in Molecular Biology
Published Date 2018-09-10
Published Volume 7
Status Always Electronic
DOI 10.12688/f1000research.15064.2
URL link to publisher's version