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Combined effects of 3D bone marrow stem cell-seeded wet-electrospun poly lactic acid scaffolds on fa-thickness skin wound healing


Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively for this purpose due to their excellent biomedical-related properties. In this study, high porous 3D poly lactic acid nanofibrous scaffolds (PLA-S) were prepared by wet-electrospinning technique and seeded with rat bone-marrow stem cells (BMSCs) to characterize the biocompatibility and therapeutic efficacy of these fibers on the treating full-thickness dermal wounds. The results of in vitro andin vivo studies indicate that the 3D fibrous PLA-S can be a potential wound dressing for wound repair, particularly when seeded with BMSCs. [GRAPHICS] .

Type Journal
ISBN 0091-4037
Authors Ghorbani, S.; Eyni, H.; Tiraihi, T.; Asl, L. S.; Soleimani, M.; Atashi, A.; Beiranvand, S. P.; Warkiani, M. E.
Responsible Garvan Author (missing name)
Publisher Name International Journal of Polymeric Materials and Polymeric Biomaterials
Published Date 2018-01-08
Published Volume 67
Published Issue 15
Published Pages 905-912
Status Always Electronic
DOI 10.1080/00914037.2017.1393681
URL link to publisher's version <Go to ISI>://WOS:000445674600005