Combined effects of 3D bone marrow stem cell-seeded wet-electrospun poly lactic acid scaffolds on fa-thickness skin wound healing
Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively for this purpose due to their excellent biomedical-related properties. In this study, high porous 3D poly lactic acid nanofibrous scaffolds (PLA-S) were prepared by wet-electrospinning technique and seeded with rat bone-marrow stem cells (BMSCs) to characterize the biocompatibility and therapeutic efficacy of these fibers on the treating full-thickness dermal wounds. The results of in vitro andin vivo studies indicate that the 3D fibrous PLA-S can be a potential wound dressing for wound repair, particularly when seeded with BMSCs. [GRAPHICS] .
|Authors||Ghorbani, S.; Eyni, H.; Tiraihi, T.; Asl, L. S.; Soleimani, M.; Atashi, A.; Beiranvand, S. P.; Warkiani, M. E.|
|Responsible Garvan Author|
|Publisher Name||International Journal of Polymeric Materials and Polymeric Biomaterials|
|URL link to publisher's version||<Go to ISI>://WOS:000445674600005|