CD44 orchestrates metastatic teamwork
Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.
|Authors||Chaffer, C. L.; Goetz, J. G.|
|Responsible Garvan Author|
|Publisher Name||DEVELOPMENTAL CELL|