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CD44 orchestrates metastatic teamwork

Abstract

Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.

Type Journal
ISBN 1534-5807
Authors Chaffer, C. L.; Goetz, J. G.
Responsible Garvan Author Dr Christine Chaffer
Publisher Name DEVELOPMENTAL CELL
Published Date 2018-12-17
Published Volume 47
Published Issue 6
Published Pages 691-693
Status Published in-print
DOI 10.1016/j.devcel.2018.11.038