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B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans

Abstract

Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are intrinsic to the B cells.

Type Journal
ISBN 1097-6825 (Electronic) 0091-6749 (Linking)
Authors Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.
Responsible Garvan Author A/Prof Tri Phan
Publisher Name JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Published Date 2019-06-01
Published Volume 143
Published Issue 6
Published Pages 2302-2305
Status Published in-print
DOI 10.1016/j.jaci.2019.02.010
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/30796983