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Visualization and Analysis of Epiproteome Dynamics

Abstract

The epiproteome describes the set of all post-translational modifications (PTMs) made to the proteins comprising a cell or organism. The extent of the epiproteome is still largely unknown; however, advances in experimental techniques are beginning to produce a deluge of data, tracking dynamic changes to the epiproteome in response to cellular stimuli. These data have potential to revolutionize our understanding of biology and disease. This review covers a range of recent visualization methods and tools developed specifically for dynamic epiproteome data sets. These methods have been designed primarily for data sets on phosphorylation, as this the most studied PTM; however, most of these methods are also applicable to other types of PTMs. Unfortunately, the currently available methods are often inadequate for existing data sets; thus, realizing the potential buried in epiproteome data sets will require new, tailored bioinformatics methods that will help researchers analyze, visualize, and interactively explore these complex data sets.

Type Journal
ISBN 1089-8638 (Electronic) 0022-2836 (Linking)
Authors Kaur, S.; Baldi, B.; Vuong, J.; O'Donoghue, S. I.
Responsible Garvan Author Prof Sean O'Donoghue
Publisher Name JOURNAL OF MOLECULAR BIOLOGY
Published Date 2019-04-05
Published Volume 431
Published Issue 8
Published Pages 1519-1539
Status Published in-print
DOI 10.1016/j.jmb.2019.01.044
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/30769119