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Human Antibody Bispecifics through Phage Display Selection


We developed a repertoire approach to generate human antibody bispecifics. Using phage display selection of antibody heavy chains in the presence of a competitor light chain and providing a cognate light chain with an affinity handle, we identified mutations that prevent heavy/light chain mispairing. The strategy allows for the selection of human antibody chains that autonomously assemble into bispecifics.

Type Journal
ISBN 1520-4995 (Electronic) 0006-2960 (Linking)
Authors Luthra, A.; Langley, D. B.; Schofield, P.; Jackson, J.; Abdelatti, M.; Rouet, R.; Nevoltris, D.; Mazigi, O.; Crossett, B.; Christie, M.; Christ, D.
Responsible Garvan Author Prof Daniel Christ
Publisher Name Biochemistry
Published Date 2019-04-02
Published Volume 58
Published Issue 13
Published Pages 1701-1704
Status Published in-print
DOI 10.1021/acs.biochem.9b00037
URL link to publisher's version