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The proliferative and apoptotic landscape of basal-like breast cancer

Abstract

Basal-like breast cancer (BLBC) is an aggressive molecular subtype that represents up to 15% of breast cancers. It occurs in younger patients, and typically shows rapid development of locoregional and distant metastasis, resulting in a relatively high mortality rate. Its defining features are that it is positive for basal cytokeratins and, epidermal growth factor receptor and/or c-Kit. Problematically, it is typically negative for the estrogen receptor and human epidermal growth factor receptor 2 (HER2), which means that it is unsuitable for either hormone therapy or targeted HER2 therapy. As a result, there are few therapeutic options for BLBC, and a major priority is to define molecular subgroups of BLBC that could be targeted therapeutically. In this review, we focus on the highly proliferative and anti-apoptotic phenotype of BLBC with the goal of defining potential therapeutic avenues, which could take advantage of these aspects of tumor development.

Type Journal
ISBN 1422-0067
Authors Alexandrou, S.; George, S. M.; Ormandy, C. J.; Lim, E.; Oakes, S. R.; Caldon, C. E.
Responsible Garvan Author Dr Liz Caldon
Publisher Name INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Published Date 2019-02-04
Published Volume 20
Published Issue 3
Published Pages 667
Status Always Electronic
DOI 10.3390/ijms20030667
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/30720718
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/14985