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The role of inflammation and endoplasmic reticulum stress in obesity-related cognitive impairment

Abstract

The epidemiological investigations and animal model experiments have confirmed the impact of obesity on the brain, behavior, and cognition. However, the mechanism by which obesity affects cognitive function is not fully understood. With the development of an aging society, there is an increase in the economic and social burden caused by the decline in cognitive function. This manuscript reviews the effects of inflammation and endoplasmic reticulum stress (ERS) on the hypothalamus, hippocampus, and the possible impact on cognitive impairment. These findings provide new insights into the pathophysiological mechanisms that lead to the development of cognitive impairment in the context of obesity.

Type Journal
ISBN 1879-0631 (Electronic) 0024-3205 (Linking)
Authors Liu, Y.; Yu, J.; Shi, Y. C.; Zhang, Y.; Lin, S.
Responsible Garvan Author Dr Yanchuan (Yan) Shi
Publisher Name LIFE SCIENCES
Published Date 2019-09-15
Published Volume 233
Published Pages 116707
Status Published in-print
DOI 10.1016/j.lfs.2019.116707
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/31374234