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Protein A superantigen: structure, engineering and molecular basis of antibody recognition


Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.

Type Journal
ISBN 1741-0134 (Electronic) 1741-0126 (Linking)
Authors Mazigi, O.; Schofield, P.; Langley, D. B.; Christ, D.
Responsible Garvan Author Prof Daniel Christ
Publisher Name Protein Eng
Published Date 2019-12-01
Published Volume 32
Published Issue 8
Published Pages 359-366
Status Published in-print
DOI 10.1093/protein/gzz026
URL link to publisher's version