PDGFRalpha Drives Pulmonary Vascular Progenitor Cells Recruitment, Vascular Remodeling and Pulmonary Hypertension Development
Introduction: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and neomuscularization. We identified pulmonary vascular progenitor cells, characterized by PW1, CD34 and PDGFRα expression, which proliferate and differentiate into smooth muscle cells (SMCs), and participate in pulmonary vessels neomuscularisation early during chronic hypoxia (CH), a mouse pulmonary hypertension model (PH).
|Authors||Julien Solinc , Jessica Raimbault-Machado , France Dierick , Lamiaa El Bernoussi , Benedicte Hoareau-Coudert , Virginie Monceau , Fabrice Atassi , Giovanna Marazzi , David A Sassoon , Richard Harvey , Daniel Christ , Peter Schofield , Catherine Pavoine , Florent Soubrier , Sophie Nadaud|
|Responsible Garvan Author|
|URL link to publisher's version||https://www.ahajournals.org/doi/abs/10.1161/circ.140.suppl_1.15717|