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PDGFRalpha Drives Pulmonary Vascular Progenitor Cells Recruitment, Vascular Remodeling and Pulmonary Hypertension Development


Introduction: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and neomuscularization. We identified pulmonary vascular progenitor cells, characterized by PW1, CD34 and PDGFRα expression, which proliferate and differentiate into smooth muscle cells (SMCs), and participate in pulmonary vessels neomuscularisation early during chronic hypoxia (CH), a mouse pulmonary hypertension model (PH).

Type Electronic article
Authors Julien Solinc , Jessica Raimbault-Machado , France Dierick , Lamiaa El Bernoussi , Benedicte Hoareau-Coudert , Virginie Monceau , Fabrice Atassi , Giovanna Marazzi , David A Sassoon , Richard Harvey , Daniel Christ , Peter Schofield , Catherine Pavoine , Florent Soubrier , Sophie Nadaud
Responsible Garvan Author Prof Daniel Christ
Publisher Name CIRCULATION
Published Date 2019-11-11
Published Volume 140
Published Issue 1
Status Always Electronic
URL link to publisher's version