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The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT

Abstract

Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplantation is the only curative treatment for most patients with these diseases. In this review, we provide a detailed update on indications and outcomes of alloHSCT for congenital neutrophil disorders, based on data from the available literature.

Type Journal
ISBN 2296-2360 (Print) 2296-2360 (Linking)
Authors Bakhtiar, S.; Shadur, B.; Stepensky, P.
Responsible Garvan Author Bella Shadur
Publisher Name Frontiers in Pediatrics
Published Date 2019-10-24
Published Volume 7
Published Pages 436
Status Always Electronic
DOI 10.3389/fped.2019.00436
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/31709206