The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT
Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplantation is the only curative treatment for most patients with these diseases. In this review, we provide a detailed update on indications and outcomes of alloHSCT for congenital neutrophil disorders, based on data from the available literature.
|ISBN||2296-2360 (Print) 2296-2360 (Linking)|
|Authors||Bakhtiar, S.; Shadur, B.; Stepensky, P.|
|Responsible Garvan Author|
|Publisher Name||Frontiers in Pediatrics|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/31709206|