The Complexities of Metastasis
Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.
|ISBN||2072-6694 (Print) 2072-6694|
|Authors||San Juan, B. P.; Garcia-Leon, M. J.; Rangel, L.; Goetz, J. G.; Chaffer, C. L.|
|Responsible Garvan Author|
|Published Pages||pii: E1575|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/31623163|