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The Complexities of Metastasis

Abstract

Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.

Type Journal
ISBN 2072-6694 (Print) 2072-6694
Authors San Juan, B. P.; Garcia-Leon, M. J.; Rangel, L.; Goetz, J. G.; Chaffer, C. L.
Responsible Garvan Author A/Prof Christine Chaffer
Publisher Name Cancers
Published Date 2019-10-16
Published Volume 11
Published Issue 10
Published Pages pii: E1575
Status Always Electronic
DOI 10.3390/cancers11101575
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/31623163