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Bioactive materials facilitating targeted local modulation of inflammation


Cardiovascular disease is an inflammatory disorder that may benefit from appropriate modulation of inflammation. Systemic treatments lower cardiac events but have serious adverse effects. Localized modulation of inflammation in current standard treatments such as bypass grafting may more effectively treat CAD. The present study investigated a bioactive vascular graft coated with the macrophage polarizing cytokine interleukin-4. These grafts repolarize macrophages to anti-inflammatory phenotypes, leading to modulation of the pro-inflammatory microenvironment and ultimately to a reduction of foreign body encapsulation and inhibition of neointimal hyperplasia development. These resulting functional improvements have significant implications for the next generation of synthetic vascular grafts.

Type Journal
ISBN 2452-302X (Electronic) 2452-302X (Linking)
Authors Tan, R. P.; Chan, A. H. P.; Wei, S.; Santos, M.; Lee, B. S. L.; Filipe, E. C.; Akhavan, B.; Bilek, M. M.; Ng, M. K. C.; Xiao, Y.; Wise, S. G.
Responsible Garvan Author Dr Elysse Filipe
Publisher Name JACC: Basic to Translational Science
Published Date 2019-02-25
Published Volume 4
Published Issue 1
Published Pages 56-71
Status Published in-print
DOI 10.1016/j.jacbts.2018.10.004
URL link to publisher's version