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The role of the extracellular matrix and the heparan sulfate proteoglycan Perlecan

Abstract

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors. One important extrinsic factor is the extracellular matrix, the non-cellular component of tissues. Heparan sulfate proteoglycans (HSPGs) are constituents of the extracellular matrix, and through their heparan sulfate chains and protein core, modulate multiple events that occur during the metastatic cascade. This review will provide an overview of the role of the extracellular matrix in the events that occur during cancer metastasis, primarily focusing on perlecan. Perlecan, a basement membrane HSPG is a key component of the vascular extracellular matrix and is commonly associated with events that occur during the metastatic cascade. Its contradictory role in these events will be discussed and we will highlight the recent advances in cancer therapies that target HSPGs and their modifying enzymes.

Type Journal
ISBN 2234-943X (Print) 2234-943X (Linking)
Authors Elgundi, Z.; Papanicolaou, M.; Major, G.; Cox, T. R.; Melrose, J.; Whitelock, J. M.; Farrugia, B. L.
Responsible Garvan Author A/Prof Thomas Cox
Publisher Name Frontiers in Oncology
Published Date 2020-01-17
Published Volume 9
Published Pages 1482
Status Always Electronic
DOI 10.3389/fonc.2019.01482
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/32010611