Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

PGC1alpha Controls Sucrose Taste Sensitization in Drosophila


Perceived palatability of food controls caloric intake. Sweet taste is the primary means of detecting the carbohydrate content of food. Surprisingly, sweet taste sensitivity is responsive to extrinsic factors like diet, and this occurs by unknown mechanisms. Here, we describe an unbiased proteomic investigation into sweet taste sensitivity in the fruit fly. We identify a dopamine/cyclic AMP (cAMP)/CREB axis acting within sweet taste neurons that controls taste perception but is largely dispensable for acute taste transduction. This pathway modulates sweet taste perception in response to both sensory- and nutrient-restricted diets and converges on PGC1alpha, a critical regulator of metabolic health and lifespan. By electrophysiology, we found that enhanced sucrose taste sensitivity was the result of heightened sweet taste intensity and that PGC1alpha was both necessary and sufficient for this effect. Together, we provide the first molecular insight into how diet-induced taste perception is regulated within the sweet taste neuron.

Type Journal
ISBN 2211-1247 (Electronic)
Authors Wang, Q. P.; Lin, Y. Q.; Lai, M. L.; Su, Z.; Oyston, L. J.; Clark, T.; Park, S. J.; Khuong, T. M.; Lau, M. T.; Shenton, V.; Shi, Y. C.; James, D. E.; Ja, W. W.; Herzog, H.; Simpson, S. J.; Neely, G. G.
Responsible Garvan Author Prof Herbert Herzog
Publisher Name Cell Reports
Published Date 2020-04-07
Published Volume 31
Published Issue 1
Published Pages 107480
Status Published in-print
DOI 10.1016/j.celrep.2020.03.044
URL link to publisher's version