Publications

Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

Molecular and cellular mechanisms underlying defective antibody responses.

Abstract

Primary immune deficiency is caused by genetic mutations that result in immune dysfunction and subsequent susceptibility to infection. Over the last decade there has been a dramatic increase in the number of genetically defined causes of immune deficiency including those which affect B‐cell function. This has not only identified critical nonredundant pathways that control the generation of protective antibody responses but also revealed that immunodeficiency and autoimmunity are often closely linked. Here we explore the molecular and cellular mechanisms of these rare monogenic conditions that disrupt antibody production, which also have implications for understanding the causes of more common polygenic immune dysfunction.

Type Electronic article
Authors Deenick, E.K.; Lau, A.; Bier, J.; Kane, A.
Responsible Garvan Author A/Prof Elissa Deenick
Publisher Name IMMUNOLOGY AND CELL BIOLOGY
Published Date 2020-04-29
Published Volume 98
Published Issue 6
Published Pages 467-479
Status Always Electronic
DOI https://doi.org/10.1111/imcb.12345