Assessment of Periprostatic and Subcutaneous Adipose Tissue Lipolysis and Adipocyte Size from Men with Localized Prostate Cancer
The prostate is surrounded by periprostatic adipose tissue (PPAT), the thickness of which has been associated with more aggressive prostate cancer (PCa). There are limited data regarding the functional characteristics of PPAT, how it compares to subcutaneous adipose tissue (SAT), and whether in a setting of localized PCa, these traits are altered by obesity or disease aggressiveness. PPAT and SAT were collected from 60 men (age: 42-78 years, BMI: 21.3-35.6 kg/m(2)) undergoing total prostatectomy for PCa. Compared to SAT, adipocytes in PPAT were smaller, had the same basal rates of fatty acid release (lipolysis) yet released less polyunsaturated fatty acid species, and were more sensitive to isoproterenol-stimulated lipolysis. Basal lipolysis of PPAT was increased in men diagnosed with less aggressive PCa (Gleason score (GS) </= 3 + 4) compared to men with more aggressive PCa (GS >/= 4 + 3) but no other measured adipocyte parameters related to PCa aggressiveness. Likewise, there was no difference in PPAT lipid biology between lean and obese men. In conclusion, lipid biological features of PPAT do differ from SAT; however, we did not observe any meaningful difference in ex vivo PPAT biology that is associated with PCa aggressiveness or obesity. As such, our findings do not support a relationship between altered PCa behavior in obese men and the metabolic reprogramming of PPAT.
|ISBN||2072-6694 (Print) 2072-6694 (Linking)|
|Authors||Miladinovic, D.; Cusick, T.; Mahon, K. L.; Haynes, A. M.; Cortie, C. H.; Meyer, B. J.; Stricker, P. D.; Wittert, G. A.; Butler, L. M.; Horvath, L. G.; Hoy, A. J.|
|Responsible Garvan Author||A/Prof Lisa Horvath|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/32481537|