Genomic Cytometry and New Modalities for Deep Single-Cell Interrogation
In the past few years, the rapid development of single-cell analysis techniques has allowed for increasingly in-depth analysis of DNA, RNA, protein, and epigenetic states, at the level of the individual cell. This unprecedented characterization ability has been enabled through the combination of cytometry, microfluidics, genomics, and informatics. Although traditionally discrete, when properly integrated, these fields create the synergistic field of Genomic Cytometry. In this review, we look at the individual methods that together gave rise to the broad field of Genomic Cytometry. We further outline the basic concepts that drive the field and provide a framework to understand this increasingly complex, technology-intensive space. Thus, we introduce Genomic Cytometry as an emerging field and propose that synergistic rationalization of disparate modalities of cytometry, microfluidics, genomics, and informatics under one banner will enable massive leaps forward in the understanding of complex biology. (c) 2020 International Society for Advancement of Cytometry.
|ISBN||1552-4930 (Electronic) 1552-4922 (Linking)|
|Authors||Salomon, R.; Martelotto, L.; Valdes-Mora, F.; Gallego-Ortega, D.|
|Responsible Garvan Author|
|Publisher Name||CYTOMETRY PART A|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/32794624|