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The Clinical Immunogenomics Research Consortium Australasia (CIRCA): a Distributed Network Model for Genomic Healthcare Delivery


The Clinical Immunogenomics Research Consortium Australasia (CIRCA) crowdsources expertise in medicine, genomics, data science, and fundamental biology to diagnose and treat patients with rare inborn errors of immunity. This distributed network model operates free of geographic borders and allows rapid progression through the full research/translation/clinical management pipeline, from initial gene variant discovery, through functional validation, and on to precision mechanism-based treatment of patients throughout Australia and New Zealand. The model is scalable and applicable to other rare diseases where clinical experience and scientific know-how are limited, and enables efficient delivery of genomics for all.

Type Journal
ISBN 1573-2592
Authors Phan, Tri Giang; Gray, Paul E.; Wong, Melanie; Macintosh, Rebecca; Burnett, Leslie; Tangye, Stuart G.; on behalf of, Circa
Responsible Garvan Author Prof Stuart Tangye
Published Date 2020-07-01
Published Volume 40
Published Issue 5
Published Pages 763-766
Status Published in-print
DOI 10.1007/s10875-020-00787-6
URL link to publisher's version