New insights on T-cell self-tolerance
Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naive cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naive and MP T cells.
|ISBN||1879-0372 (Electronic) 0952-7915 (Linking)|
|Authors||Yi, J.; Kawabe, T.; Sprent, J.|
|Responsible Garvan Author||Prof Jonathan Sprent|
|Publisher Name||CURRENT OPINION IN IMMUNOLOGY|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/31786417|