Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

Myosin XVIII


Class XVIII myosins represent a branch of the myosin family tree characterized by the presence of large N- and C-terminal extensions flanking a generic myosin core. These myosins display the highest sequence similarity to conventional class II muscle myosins and are compatible with but not restricted to myosin-2 contractile structures. Instead, they fulfill their functions at diverse localities, such as lamella, actomyosin bundles, the Golgi apparatus, focal adhesions, the cell membrane, and within sarcomeres. Sequence comparison of active-site residues and biochemical data available thus far indicate that this myosin class lacks active ATPase-driven motor activity, suggesting that its members function as structural myosins. An emerging body of evidence indicates that this structural capability is essential for the organization, maturation, and regulation of the contractile machinery in both muscle and nonmuscle cells. This is supported by the clear association of myosin-18A (Myo18A) and myosin-18B (Myo18B) dysregulation with diseases such as cancer and various myopathies.

Type Journal
ISBN 0065-2598 (Print) 0065-2598 (Linking)
Authors Taft, M. H.; Latham, S. L.
Responsible Garvan Author Dr Sharissa Latham
Publisher Name Advances in Experimental Medicine and Biology
Published Date 2020-05-01
Published Volume 1239
Published Pages 421-438
Status Published in-print
DOI 10.1007/978-3-030-38062-5_19
URL link to publisher's version