Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

Trifluridine/tipiracil: A practical guide to its use in the management of refractory metastatic colorectal cancer in Australia


Trifluridine/tipiracil is available on the Australian Pharmaceutical Benefits Scheme for the treatment of patients with metastatic colorectal cancer (mCRC) previously treated with, or not considered candidates for, fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-vascular endothelial growth factor agents and anti-epidermal growth factor receptor agents. This article reviews trifluridine/tipiracil clinical data and presents practical information on its use in the management of refractory mCRC in Australia. Whereas the primary mechanism of action of fluoropyrimidines such as fluorouracil (5-FU) and capecitabine is enzyme inhibition of nucleotide synthesis, trifluridine/tipiracil primarily acts by incorporation into DNA, resulting in DNA dysfunction. Trifluridine/tipiracil has activity in patients with 5-FU-resistant tumors and can be considered in patients with prior intolerance or toxicity to 5-FU. In the pivotal phase III RECOURSE trial evaluating trifluridine/tipiracil in chemotherapy-refractory mCRC, efficacy benefits were observed across all a priori prognostic subgroups including those defined by age (>/=65 and >/=75 years), geographical origin, primary tumor site or KRAS status. Trifluridine/tipiracil therapy benefits appropriately selected patients who have an ECOG performance status of 0 or 1, with no more than mild hepatic impairment or mild-to-moderate renal impairment, and who are capable of adhering to oral therapy safely. Appropriate dosing, monitoring for adverse events and effective management of side effects are essential.

Type Journal
ISBN 1743-7563 (Electronic) 1743-7555 (Linking)
Authors Price, T.; Burge, M.; Chantrill, L.; Gibbs, P.; Pavlakis, N.; Shapiro, J.; Sjoquist, K.
Publisher Name Asia-Pacific Journal of Clinical Oncology
Published Date 2020-04-01
Published Volume 16 Suppl 1
Published Pages 3-12
Status Published in-print
DOI 10.1111/ajco.13336
URL link to publisher's version