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Is Dietary Vitamin A Associated with Myopia from Adolescence to Young Adulthood?


Purpose: Potential links may exist between vitamin A intake and myopia via various pathways. In this study, we examined the association between dietary vitamin A intake during adolescence and myopia in early adulthood. Methods: We performed a prospective analysis utilizing data collected from participants of the Raine Study Gen2. Dietary vitamin A intake, determined via food frequency questionnaires completed at ages 14, 17, and 20 years, was compared with ophthalmic measurements collected at year 20. Low vitamin A levels were defined as <600 microg/day. Regression models were used to adjust for ocular sun exposure level, educational level, and parental myopia as potential confounders. Results: A total of 642 subjects were analyzed. Although those with adequate vitamin A intakes were less likely to be myopic (P = 0.03), this association became insignificant when adjusted for potential confounding factors in logistic regression modeling (odds ratio, 0.59; 95% confidence interval, 0.98-2.52; P = 0.06). Conclusions: There were no significant associations between total vitamin A intakes during adolescence and year 20 refractive errors after adjustment for confounders. Replication of this finding and further investigations are essential to rule out the suggestion that sufficient vitamin A intake during adolescence is associated with lower risk of myopia in early adulthood. Translational Relevance: Our findings are not definitive that ingesting foods high in vitamin A during childhood and adolescence does not have a role for preventing myopia in early adulthood.

Type Journal
ISBN 2164-2591 (Print) 2164-2591 (Linking)
Authors Ng, F. J.; Mackey, D. A.; O'Sullivan, T. A.; Oddy, W. H.; Yazar, S.
Responsible Garvan Author Dr Seyhan Yazar
Publisher Name Translational Vision Science & Technology
Published Date 2020-05-31
Published Volume 9
Published Issue 6
Published Pages 29
Status Published in-print
DOI 10.1167/tvst.9.6.29
URL link to publisher's version