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Intraocular solitary extramedullary plasmacytoma presenting as unilateral anterior and intermediate uveitis preceded by refractory glaucoma


BACKGROUND: Solitary extramedullary plasmacytoma (SEP) is a localised proliferation of monoclonal plasma cells involving soft tissue with no or minimal bone marrow involvement and no other systemic evidence of multiple myeloma. Intraocular involvement is exceedingly rare. CASE PRESENTATION: We report a 78-year-old man who was referred with glaucoma in the right eye. He subsequently developed anterior chamber (AC) inflammation and refractory glaucoma then dense vitritis. A vitrectomy was performed with the biopsy revealing numerous plasma cells with atypical findings. In conjunction with the flow cytometry results, and a systemic work up excluding multiple myeloma, a diagnosis of SEP was made. The patient was treated with ocular external beam radiotherapy with resolution of the intraocular inflammation and control of the intraocular pressure. He remains well with no local recurrence and no development of multiple myeloma over a follow up period of 2.5 years. CONCLUSIONS: This is the first case report of SEP presenting as intraocular inflammation without a uveal tract mass.

Type Journal
Authors Ayton, T. Cherepanoff, S. Gottlieb, D. Sewell, W. A. Smith, S. Hooper, C.
Responsible Garvan Author Prof Bill Sewell
Publisher Name BMC Ophthalmology
Published Date 2021-01-30
Published Volume 21
Published Issue 1
Published Pages 66
Status Published in-print
DOI 10.1186/s12886-021-01822-9