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Ninjin'yoeito modulates feeding and activity under negative energy balance conditions via the NPY system

Abstract

The central and peripheral neuropeptide Y (NPY) system is critically involved in feeding and energy homeostasis control. Disease conditions as well as aging can lead to reduced functionality of the NPY system and boosting it represents a promising option to improve health outcomes in these situations. Here we show that Ninjin-yoeito (NYT), a Japanese kampo medicine comprising twelve herbs, and known to be effective to treat anorexia and frailty, mediates part of its action via NPY/peptide YY (PYY) related pathways. Especially under negative energy homeostasis conditions NYT is able to promote feeding and reduces activity to conserve energy. These effects are in part mediated via signalling through the NPY system since lack of Y4 receptors or PYY leading to modification in these responses highlighting the possibility for combination treatment to improve aging related conditions on energy homeostasis control.

Type Journal
ISBN 1532-2785 (Electronic) 0143-4179 (Linking)
Authors Zhang, L.; Clark, T.; Gopalasingam, G.; Neely, G. G.; Herzog, H.
Responsible Garvan Author Prof Herbert Herzog
Publisher Name NEUROPEPTIDES
Published Date 2021-06-07
Published Volume 87
Published Pages 102149
Status Published in-print
DOI 10.1016/j.npep.2021.102149
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/33882337