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B cells in the spotlight: innocent bystanders or major playe...
May 08, 2013 12:45 PM
It has long been established that type 1 diabetes (T1D) is a T cell-mediated autoimmune disease, with CD4+ and CD8+ T cells being largely responsible for the destruction of beta cells within the pancreatic islets of Lang...
The diagnosis of farmer's lung
May 08, 2013 12:44 PM
Parkinson's real lives
Dec 18, 2017 02:30 PM
Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies ar...
‘Forgotten molecule’ takes centre stage in cancer gene s...
Sep 08, 2016 09:29 AM
Research from Garvan’s Genomics and Epigenetics Division has shed new light on how genes are silenced in cancer. The findings reveal how DNA becomes chemically decorated (methylated) at key sites across the genome in c...
Insulin levels in insulin resistance: phantom of the metabol...
May 08, 2013 12:45 PM
Insulin resistance is considered a core component in the pathophysiology of the metabolic syndrome. Some clinicians measure serum insulin concentrations in the mistaken belief that they can be used to diagnose insulin re...
Impact of short-term estrogen administration on growth hormo...
May 08, 2013 12:44 PM
We recently reported that estrogen exerts distinct effects on the GH/IGF-1 axis that are dependent on the route of delivery, probably reflecting a first-pass effect on hepatic IGF-1 production. Oral administration reduce...
Angiotensinogen secretion by single rat pituitary cells: det...
May 08, 2013 12:44 PM
A reverse haemolytic plaque assay (RHPA) for angiotensinogen was developed in rat hepatoma H4 cells and applied to investigate the possible secretion of angiotensinogen from rat pituitary cells in primary culture. Over a...
Bovine myoclonus: a model of human hyperekplexia (startle di...
May 08, 2013 12:45 PM
The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic target. However, its clinical exploitation is contingent upon the discovery of context...
Aside from glucose metabolism, insulin regulates a variety of pathways in peripheral tissues. Under insulin-resistant conditions, it is well known that insulin-stimulated glucose uptake is impaired, and many studies attr...
Pathogenesis and management of hyperparathyroidism in end st...
May 08, 2013 12:45 PM
Preeclampsia is a hypertensive disorder of pregnancy that affects 3-5% of all pregnancies. There is evidence to suggest that epigenetic mechanisms, such as DNA methylation, play a role in placental development and functi...
Lineage specification and heterogeneity of T follicular help...
May 08, 2013 12:46 PM
T follicular helper (Tfh) cells were originally described as a non-polarized CD4(+) T cell subset with follicular homing capacity and a potent ability to induce antibody production from B cells. However, a number of stud...
Human Th9 cells: inflammatory cytokines modulate IL-9 produc...
May 08, 2013 12:46 PM
The weak complex between RhoGAP protein ARHGAP22 and signal ...
May 08, 2013 12:46 PM
ARHGAP22 is a RhoGAP protein comprising an N-terminal PH domain, a RhoGAP domain and a C-terminal coiled-coil domain. It has recently been identified as an Akt substrate that binds 14-3-3 proteins in response to treatmen...
