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Effects of continuous activation of vitamin D and Wnt respon...
May 08, 2013 12:46 PM
The Wnt pathway regulates cell proliferation and differentiation in development and disease, with a number of recent reports linking Wnt to control of osteoblast differentiation and bone mass. There is also accumulating ...
The production of high affinity monoclonal antibodies to hum...
May 08, 2013 12:44 PM
The primary aim of this work was to produce specific monoclonal antibodies to human growth hormone (hGH) for use in a diagnostic RIA of hGH levels in serum. Three different schedules were used for immunization of BALB/c ...
Do gene-environment interactions influence fasting plasma li...
May 08, 2013 12:45 PM
BACKGROUND: The aims of this study were to determine the influence of smoking, alcohol consumption, physical activity and hormone replacement therapy (HRT) on lipids, independently of genetic factors, and to detect wheth...
Addison's disease is associated with low bone mineral density and increased risk of hip fractures. Causes are multifactorial, contributed by underlying adrenocortical hormonal deficiency, associated autoimmune endocrinop...
The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome. Whereas canonical NF-κB signa...
AIM: To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease. METHODS: We compared rates of gastrointestinal perforation in...
A role for GATA-2 in transition to an aggressive phenotype i...
May 08, 2013 12:46 PM
GATA-2, a member of the GATA family of transcription factors, plays an essential role in hematopoiesis. Recent studies have indicated that GATA-2 is involved in the androgen receptor (AR) signaling cascade, however, litt...
Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout ...
May 08, 2013 12:46 PM
Neuropeptide Y (NPY) was shown to modulate anxiety- and depression-related behaviors in various animal models. Previous studies demonstrated that NPY Y2 receptor knockout (KO) mice display an anxiolytic- and antidepressa...
Myc oncoproteins and histone deacetylases (HDACs) exert oncogenic effects by modulating gene transcription. Paradoxically, N-Myc induces p53 gene expression. Tumor protein 53-induced nuclear protein 1 (TP53INP1) phosphor...
Androgen receptor expression predicts breast cancer survival...
May 08, 2013 12:46 PM
Peak bone mass and osteoporosis prevention
May 08, 2013 12:44 PM
The incidence of osteoporotic fractures increases with advancing age. Despite advances in therapy, reversal of bone loss in established osteoporosis remains problematic and deformities and disability due to fractures oft...
OBJECTIVE: We have recently shown that acute inhibition of both mTOR complexes (mTORC1 and mTORC2) increases whole-body lipid utilization, while mTORC1 inhibition had no effect. Therefore, we tested the hypothesis that m...
Osteoporosis
Feb 28, 2018 02:31 PM
Get the facts on osteoporosis, risks and symptoms, and Garvan's collaborative research. We study the genetics of fracture risk and bone mass & quality, as well as co-existing diseases.
Chronic effects of fatty acids on pancreatic beta-cell funct...
May 08, 2013 12:45 PM
Type 2 diabetes can be viewed as a failure of the pancreatic beta-cell to compensate for peripheral insulin resistance with enhanced insulin secretion. This failure is explained by both a relative loss of beta-cell mass ...
Neuroinflammation and neuronal loss precede Abeta plaque dep...
Dec 02, 2013 03:09 PM
Abstract
Recent human trials of Alzheimer?s disease (AD) treatments have largely failed, raising the idea that treatment may need to be started earlier in the disease process, well before cognitive symptoms appear. An ea...
