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Alterations in the neurotrophic factors BDNF, GDNF and CNTF ...
May 08, 2013 12:45 PM
Neurogenesis, axonal outgrowth and synapse formation are usually restricted to specific stages during central nervous system development, but the mature olfactory system maintains these capacities. The cycle of neuronal ...
There is now compelling evidence that the molecular heterogeneity of cancer is associated with disparate phenotypes with variable outcomes and therapeutic responsiveness to therapy in histologically indistinguishable can...
Deletion of protein kinase Cepsilon in mice has limited effe...
May 08, 2013 12:46 PM
AIMS/HYPOTHESIS: Protein kinase Cepsilon (PKCepsilon) is emerging as a key mediator of lipid-induced insulin resistance in liver and hepatic lipid metabolism itself. We investigated whether PKCepsilon plays a role in oth...
The response of neuregulin 1 mutant mice to acute restraint ...
May 08, 2013 12:46 PM
Stress plays a role in the development and severity of psychotic symptoms and there may be a genetic component to stress vulnerability in schizophrenia. Using an established mouse model for schizophrenia, we investigated...
Genetic profiling and individualized prognosis of fracture
May 08, 2013 12:46 PM
Fragility fracture is a serious public health problem in the world. The risk of fracture is determined by genetic and non-genetic clinical risk factors. The present study sought to quantify the contribution of genetic pr...
PKCdelta blues for the beta-cell
May 08, 2013 12:46 PM
Osteoporotic fracture: missed opportunity for intervention
May 08, 2013 12:45 PM
As prior fracture is consistently associated with increased risk of subsequent fracture, subjects with a history of prior fracture represent a high risk group which should be targeted for intervention to reduce future fr...
Sick day management for patients with diabetes
May 08, 2013 12:45 PM
In this article we consider some of the central issues in dealing with patients with diabetes when they get sick. In approaching the problem, we have also attempted to highlight the difference in managing type 1 and type...
Blood glucose regulation in diabetics using an artificial pa...
May 08, 2013 12:44 PM
Vitamin D receptor alleles and bone physiology
May 08, 2013 12:45 PM
The vitamin D endocrine system is central to the control of bone and calcium homeostasis. The active hormonal form of vitamin D, 1,25 dihydroxyvitamin D (calcitriol), the circulating level of which is tightly regulated, ...
Targeted inactivation of Gh/tissue transglutaminase II
May 08, 2013 12:45 PM
The novel G-protein, G(h)/tissue transglutaminase (TGase II), has both guanosine triphosphatase and Ca(2+)-activated transglutaminase activity and has been implicated in a number of processes including signal transductio...
Estrogen regulation of cell cycle progression in breast canc...
May 08, 2013 12:45 PM
Estrogens are potent mitogens in a number of target tissues including the mammary gland where they play a pivotal role in the development and progression of mammary carcinoma. The demonstration that estrogen-induced mito...
Progestin regulation of cellular proliferation
May 08, 2013 12:44 PM
In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mice all developed glucose intolerance, while BALB/c mice displayed minimal deterioration in glucose tolerance and insulin...
Next-generation Akt inhibitors provide greater specificity: ...
May 08, 2013 12:46 PM
Many human tumours exhibit activation of the PI3K (phosphoinositide 3-kinase)/Akt pathway, and inhibition of this pathway slows tumour growth. This led to the development of specific Akt inhibitors for in vivo use. Howev...
Identification of novel ERK2 substrates through use of an en...
May 08, 2013 12:45 PM
The mitogen-activated protein kinases are key regulators of cellular organization and function. To understand the mechanisms(s) by which these ubiquitous kinases affect specific cellular changes, it is necessary to ident...
