Beta Cell Regeneration
Pancreatic beta-cells secrete insulin to regulate energy utilization throughout the body. This critical cell-type is destroyed (type 1) or insufficient (type 2) in the common forms of diabetes. A major focus of our work is to devise strategies for beta-cell regeneration.
We use genetic, pharmacological and high resolution imaging approaches in zebrafish to provide proof-of-principle for new therapeutic strategies. Together with other groups at Garvan we are taking drugs identified in high-throughput zebrafish screens into validated pre-clinical disease models for further testing.
In addition, we are interested in identifying and then modulating dysregulated pathways that are shared between diabetes and neurodegenerative conditions such as Parkinson's disease.
In the News
Garvan receives $15.5 million in NHMRC funding round - Oct 25, 2013
Dr Tim Mercer wins 2013 Young Garvan Award - Jul 16, 2013