CLINICAL INSULIN RESISTANCE
Research at the Clinical Insulin Resistance Group is focused on uncovering the molecular pathways involved in the transition from health to insulin resistance and metabolic disease related to overweight and obesity in humans. We perform cross-sectional, longitudinal and short-term nutritional interventions to uncover the factors that protect metabolically-healthy individuals with obesity from developing diabetes and cardiovascular disease.
We have developed and established deep phenotyping tools to characterise glucose and energy homoeostasis and body fat distribution in humans. Aiming to improve health in individuals at risk of developing type 2 diabetes, we explore the molecular and metabolic factors that explain the diverse phenotypes of obesity and pre-diabetes. Findings may help explain why some people remain non-responsive to common current treatments and result in precision medicine and treatment success.
Chen DL, Brown R, Liess C, Poljak A, Xu A, Zhang J, Trenell M, Jenkins A, Chisholm D, Samocha-Bonet D, Macefield VG, Greenfield JR. Muscle sympathetic nerve activity is associated with liver insulin sensitivity in obese non-diabetic men. Front Endocrinol 2017; 8: 101.
Tonks KT, White CP, Centre JR, Samocha-Bonet D, Greenfield JR. Bone turnover is suppressed in insulin resistance, independent of adiposity. J Clin Endocrinol Metab 2017 102 (4) 1112-1121.
Tam CS, Chaudhuri R, Hutchison AT, Samocha-Bonet D, Heilbronn LK. Skeletal muscle extracellular matrix remodelling after short-term overfeeding in healthy humans. Metabolism 2017 Feb; 67:26-30.
MacKie GM, Samocha-Bonet D, Tam C. Does weight cycling promote obesity and metabolic disease? Obesity Research & Clinical Practice 2017 11(2) 131-139 Review.
Tonks KT, Coster ACF, Christopher MJ, Chaudhuri R, Xu A, Gagnon-Bartsch J, Chisholm DJ, James DE, Meikle PJ, Greenfield JR, Samocha-Bonet D. Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans. Obesity 2016. 24(4):908-16.
Chen DL, Liess C, Poljak A, Xu A, Zhang J, Thoma C, Trenell M, Milner B, Jenkins AB, Chisholm DJ, *Samocha-Bonet D, *Greenfield JR Phenotypic characterization of insulin-resistant and insulin-sensitive obesity. J Clin Endocrinol Metab 2015 100(11):4082-91.
Williams RS, Heilbronn LK, Chen DL, Coster AC, Greenfield JR, Samocha-Bonet D Dietary acid load, metabolic acidosis and insulin resistance - lessons from cross-sectional and overfeeding studies in humans. Clin Nutr Aug 12. pii: S0261-5614(15)00218-6. doi: 10.1016/j.clnu.2015.08.002.
Samocha-Bonet D, Chisholm DJ, Holst JJ, Greenfield JR L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients Nutrients 2015 7(4):2101-8
Samocha-Bonet D, Chisholm DJ, Gribble FM, Coster AC, Carpenter KH, Jones GR, Holst JJ, Greenfield JR Glycemic Effects and Safety of L-Glutamine Supplementation with or without Sitagliptin in Type 2 Diabetes Patients-A Randomized Study PLoS One 2014 9(11):e113366.
Samocha-Bonet D, Dixit VD, Kahn CR, Leibel RL, Lin X, Nieuwdorp M, Pietiläinen KH, Rabasa-Lhoret R, Roden M, Scherer PE, Klein S, Ravussin E. Metabolically healthy and unhealthy obese - the 2013 Stock Conference report. Obes Rev 2014 15(9):697-708.
Samocha-Bonet D, Tam CS, Campbell LV, Heilbronn LK. Raised circulating fetuin-A after 28-day overfeeding in healthy humans Diabetes Care 2014 37:e15-16
Heilbronn LK, Campbell LV, Xu A, Samocha-Bonet D Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased by acute overfeeding in healthy humans. PLoS One 2013 8:e78864
Heilbronn LK, Coster ACF, Campbell LV, Greenfield JR, Lange K, Christopher MJ, Meikle PJ, Samocha-Bonet D. The effect of short term overfeeding on serum lipids in healthy humans. Obesity 2013 21:E649-659
Hocking S, Samocha-Bonet D, Milner K-L, Greenfield JR, Chisholm DJ. Adiposity and Insulin Resistance in Humans: The Role of the Different Tissue and Cellular Lipid Depots. Endo Rev 2013; 34:463-500.
Samocha-Bonet D, Chisholm DJ, Tonks K, Campbell LV, Greenfield JR. Insulin-sensitive obesity in humans - a 'favorable fat' phenotype? Trends Endocrinol Metab 2012; 23:116-124.
Samocha-Bonet D, Campbell LV, Mori TA, Croft KD, Greenfield JR, Turner N, Heilbronn LK. Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans. PLoS One 2012; 7:e36320.
Tam CS, Viardot A, Clement K, Tordjman J, Tonks K, Greenfield JR, Campbell LV, Samocha-Bonet D, Heilbronn LK. Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans. Diabetes 2010; 59:2164-2170.
Samocha-Bonet D, Heilbronn LK, Lichtenberg D, Campbell LV. Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals? Trends Endocrinol Metab 2010; 21(2):83-87.
Samocha-Bonet D, Campbell LV, Viardot A, Freund J, Tam CS, Greenfield JR, Heilbronn LK. A family history of type 2 diabetes increases risk factors associated with overfeeding. Diabetologia 2010; 53:1700-1708.
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