Dr Jeng Yie Chan

Research Officer

Jeng Yie completed her undergraduate studies at the University of Adelaide before moving to Sydney. She completed a PhD on beta cell function and survival under stress conditions typically associated with diabetes.

Currently, Jeng Yie is undertaking her postdoctoral research aimed to better understand the mechanisms underlying beta cell failure in type 1 and type 2 diabetes.

Research Interests

• Type 1 Diabetes
• Type 2 Diabetes
• Endoplasmic Reticulum Stress
• Unfolded Protein Response
• Beta Cell Death
• Inflammation
• Insulin Secretion
• Beta Cell Differentiation

Awards and Honours

2011 - Australian Diabetes Society Pincus Taft Young Investigator Award
2011 - Australian Islet Study Group Young Investigator Award
2010 - Australian Islet Study Group Young Investigator Award
2010 - University of New South Wales Commercialisation Training Scheme Scholarship
2009 - Australian Islet Study Best Student Poster Prize
2009 - NHMRC Biomedical Postgraduate Scholarship


2013 - PhD, University of New South Wales - Australia
2012 - Graduate Certificate in Research Management and Management, University of New South Wales - Australia
2007 - BHlthSci (Honours), University of Adelaide - Australia
2006 - BSc (Biotechnology), University of Adelaide - Australia

Selected Publications

Chan JY, Luzuriaga J, Maxwell EL, West PK, Bensellam M, Laybutt DR, 2015. The balance between adaptive and apoptotic unfolded protein responses regulates beta cell death through XBP1, CHOP and JNK. Molecular and Cellular Endocrinology; 413:189-201.

Bensellam M., Montgomery M, Luzuriaga J, Chan JY, Laybutt DR, 2015. ID proteins protect against oxidative stress by regulating the antioxidant-mitochondrial response in beta-cells. Diabetologia; 58(4):758-70.

Walters SN, Luzuriaga J, Chan JY, Grey ST, Laybutt DR. Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets. J Mol Endocrinol 2013; 51(2):225-32.

Chan JY, Luzuriaga J, Bensellam M, Biden TJ, Laybutt DR. Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes. Diabetes 2013; 62(5): 1557-68.

Chan JY, Biden TJ, Laybutt DR. Cross-talk between the unfolded protein response and nuclear factor-kB signalling pathways regulates cytokine-mediated beta cell death. Diabetologia 2012; 55(11):2999-3009.

Chan JY, Cooney GJ, Biden TJ, Laybutt DR. Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells. Diabetologia 2011; 54(7):1766-76.

Åkerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR. Cytokine-induced β-cell death is independent of endoplasmic reticulum stress signalling. Diabetes 2008; 57(11):3034-44.

Dr Jeng Yie Chan