Dr Martin Whitham

Following undergraduate and post graduate training at the University of Glasgow, University of North Carolina at Chapel Hill, and University of Birmingham, Martin initially held a tenured academic appointment at Bangor University (UK). Following a sabbatical at the BakerIDI Heart and Diabetes Instit
Group Leader - Myokine Biology

Following undergraduate and post graduate training at the University of Glasgow, University of North Carolina at Chapel Hill, and University of Birmingham, Martin initially held a tenured academic appointment at Bangor University (UK). Following a sabbatical at the BakerIDI Heart and Diabetes Institute (Australia) with Professor Mark Febbraio, this paved the way for his appointment as Senior Research Officer. In ARC discovery grant funded work, he developed interest and expertise in Proteomics with a view to screening skeletal muscle for Myokines – proteins released from muscle that signal in other tissues. Following a move to Garvan Institute of Medical Research in 2015, he was appointed Group Leader of the Myokine Biology group in the Diabetes and Metabolism Division. His primary interests are in the role of small vesicles, exosomes and peptides in inter-tissue signalling in health and disease.

Research Interests

Exercise Physiology
Proteomics
Obesity
Insulin resistance

Education

2002 - PhD, University of Birmingham - UK
1999 - BSc (Hons), University of Glasgow - UK

Selected Publications

Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron LNN, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA (2018). Extracellular vesicles provide a means for tissue cross talk during exercise. Cell Metabolism 27: 237-251 Access the recommendation on F1000Prime 3* Exceptional Recommendation

Whitham, M., Febbraio, M.A. The ever expanding myokinome: discovery challenges and therapeutic implications. Nature Rev. Drug Discov. 15: 719-729 (2016)

Henstridge, D. C.*, Whitham, M*. & Febbraio, M. A. Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes. Molecular Metabolism 3, 781–93 (2014)

Pal, M., Febbraio, M. A. & Whitham, M. From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation. Immunology and Cell Biology 92,331-339  (2014).

Kraakman, M.J, Allen, T.L, Whitham, M, Iliades, P, Kammoun, H.L, Estevez, E, Lancaster, G.I, Febbraio, M.A (2013) Targeting gp130 to prevent inflammation and promote insulin action. Diabetes, Obesity and Metabolism 15(suppl 3) 170-175

Whitham, M.*, Chan, M.H.S*, Pal, M, Matthews, V.B, Prelovsek, O, Lunke, S, El-Osta, A, Broenneke, H, Alber, J, Bruning, J.C, Wunderlich, F.T, Lancaster, G.I & Febbraio, M.A (2012) Contraction induced IL-6 gene transcription in skeletal muscle is regulated by c-jun terminal kinase/Activator protein-1. Journal of Biological Chemistry  287 10771-10779. doi: 10.1074/jbc.M111.310581 

Allen, T.L., Whitham, M. & Febbraio, M.A (2012) IL-6 muscles in on the gut and pancreas to enhance insulin secretion. Cell Metabolism 15(1) 8-9

Hansen, J., Brandt, C., Nielsen, A.R., Hojman, P., Whitham, M., Febbraio, M.A, Pedersen, B.K., and Plomgaard, P. (2011) Exercise induces a marked increase in plasma follistatin: evidence that follistatin is a contraction-induced hepatokine. Endocrinology 152(1), 164-71

Fortes, M.B. & Whitham, M. (2011) Salivary Hsp72 does not track exercise stress and caffeine stimulated plasma Hsp72 responses in humans. Cell Stress & Chaperones 16(3):345-52

Fortes, M.B. & Whitham, M. (2009) No endogenous circadian rhythm in resting plasma Hsp72 concentration in humans. Cell Stress and Chaperones (2009) 14(3): 273

Whitham, M. & Fortes, M.B. (2008) Heat shock protein 72 : Release and biological significance during exercise. Frontiers in Bioscience 13: 1328-39

Laing, S.J, Jackson, A.R, Walters, R, Lloyd-Jones, E, Whitham, M Maassen, N and Walsh, N.P (2008) Human blood neutrophil responses to prolonged exercise with and without a thermal clamp. Journal of Applied Physiology 104(1), 20-26.

Whitham, M., Laing, S.L., Jackson, A., Maassen, N., & Walsh, N.P. (2007) Effect of exercise with and without a thermal clamp on the plasma heat shock protein 72 response. Journal of Applied Physiology 103(4),1251-56.

Whitham, M. & McKinney, J. (2007) Effect of a carbohydrate mouthwash on running time trial performance Journal of Sports Sciences 25(12),1385-92.

Whitham, M. & Fortes, M. (2006) Effect of blood handling on extracellular heat shock protein 72 concentration following high intensity exercise in humans. Cell stress and chaperones 11 (4), 304-308

Whitham, M, Walker, G.J, & Bishop, N.C (2006) Effect of caffeine supplementation on the extracellular heat shock protein 72 response to exercise. Journal of Applied Physiology 101: 1222-1227

Walsh, NP, & Whitham M (2006) Exercising in extreme environments: A greater threat to immune function? Sports Medicine 36(11) 941-976

Person portrait

Dr Martin Whitham