Dr Clare Stirzaker
Senior Research Officer
Clare completed her Bachelor of Science majoring in Biochemistry and Microbiology, and her Bachelor of Science with First Class Honours in Molecular Biology, at the University of Cape Town, South Africa, before completing her PhD at Macquarie University, Sydney, graduating in 1990.
Clare became fascinated by the field of Epigenetics and joined the group of Prof Susan Clark as a post-doc at the Kanematsu Laboratories, Royal Prince Alfred Hospital, in Sydney and later, at the Sydney Cancer Centre at Sydney University. The group moved to the Garvan Institute of Medical Research in 2004, where an Epigenetics Group was established within the Cancer Program. Clare has since established her own group, which is interested in understanding "Epigenetic Deregulation in Cancer."
Clare has played a major role in delivery of many of the milestones in epigenetic research. She has made highly significant contributions to the field of DNA methylation and epigenetic deregulation in cancer and has also played an integral role in developing new epigenetic technologies that have underpinned many of the seminal findings of the group.
Clare is involved in a number of collaborative projects which include an NBCF project grant ‘Enabling Clinical Epigenetic Diagnostics: The Next Generation of Personalised Breast Cancer Care’ and an NHMRC project grant with Monash University ‘Defining Epigenetic Changes in Prostate Cancer Stroma.’
In the News‘Forgotten molecule’ takes centre stage in cancer gene silencing - Sep 08, 2016
Epigenetics enters the arena of personalised medicine - Jul 01, 2016
A 3D view of the cancer genome - Jun 06, 2016
Garvan Institute scientists receive $10.7 million in NHMRC funding - Oct 22, 2014
Garvan receives $15.5 million in NHMRC funding round - Oct 25, 2013
What it might take to unravel the ‘lean mean machine’ that is cancer - Feb 22, 2010
1982 - BSc First Class Honours (Major: Molecular Biology), University of Cape Town - South Africa
1981 - BSc (Majors: Biochemistry and Microbiology), University of Cape Town - South Africa
BLUEPRINT consortium. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. Nat Biotechnol 2016; epub ahead of print
Taberlay PC, Achinger-Kawecka J, Lun AT, Buske FA, Sabir K, Gould CM, Zotenko E, Bert SA, Giles KA, Bauer DC, Smyth GK, Stirzaker C, O'Donoghue SI, Clark SJ. Three-dimensional disorganisation of the cancer genome occurs coincident with long-range genetic and epigenetic alterations. Genome Res 2016; 26:719-31
Stone A, Zotenko E, Locke WJ, Korbie D, Millar EK, Pidsley R, Stirzaker C, Graham P, Trau M, Musgrove EA, Nicholson RI, Gee JM, Clark SJ. DNA methylation of oestrgen-regulated enhancers defines endocrine sensitivity in breast cancer. Nat Commun 2015; 6:7758
Stirzaker C, Zotenko E, Clark SJ. Genome-wide DNA methylation profiling in triple-negative breast cancer reveals epigenetic signatures with important clinical value. Mol Cell Oncol 2015; 3:e1038424
Stirzaker C*, Zotenko E*, Song JZ, Qu W, Nair SS, Locke WJ, Stone A, Armstong NJ, Robinson MD, Dobrovic A, Avery-Kiejda KA, Peters KM, French JD, Stein S, Korbie DJ, Trau M, Forbes JF, Scott RJ, Brown MA, Francis GD, Clark SJ. Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value. Nat Comm 2015; 6:5899 Equal *first authors
Locke WJ, Zotenko E, Stirzaker C, Robinson MD, Hinshelwood RA, Stone A, Reddel RR, Huschtscha LI, Clark SJ. Coordinated epigenetic remodelling of transcriptional networks occurs durng early breast carcinogenesis. Clin Epigenetics 2015; 7:52
Du Q, Luu PL, Stirzaker C, Clark SJ. Methyl-CpG-binding domain proteins: readers of the epigenome. Epigenomics 2015; 7:1051-73
Korbie D, Lin E, Wall D, Nair SS, Stirzaker C, Clark SJ, Trau M. Multiplex bisulfate PCR resequencing of clinical FFPE DNA. Clin Epigenetics 2015; 7:28
Stirzaker C*, Taberlay PC*, Statham AL, Clark SJ. Mining Cancer Methylomes: Prospects and Challenges. Trends Genet 2013; 30:75-84 *authors contributed equally to the work.
Bert SA, Robinson MD, Strbenac D, Statham AL, Song JZ, Hulf T, Sutherland RL, Coolen MW, Stirzaker C, Clark SJ. Regional Activation of the Cancer Genome by Long Range Epigenetic Remodelling. Cancer Cell 2013; 23:9-22
Hulf T, Sibbritt T, Wiklund ED, Patterson K, Song JZ, Stirzaker C, Qu W, Nair S, Horvath LG, Armstrong NJ, Kench JG, Sutherland RL, Clark SJ. Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer. Oncogene. 2012; 32:2891-9
Statham AL*, Robinson MD*, Song JZ, Coolen MW, Stirzaker C#, Clark SJ#. Bisulphite-sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA. Genome Res 2012; 22:1120-7 Equal *first authors and #last authors
Valdés-Mora F, Song JZ, Statham AL, Strbenac D, Robinson MD, Nair SS, Patterson KI, Tremethick DJ, Stirzaker C, Clark SJ. Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodelling in cancer. Genome Res 2012; 22:307-21
Devaney J*, Stirzaker C*, Qu W, Song JZ, Statham AL, Patterson KI, Horvath LG, Tabor B, Coolen MW, Kench JG, Henshall SM, Pe Benito R, Haynes A-M, Mayor R, Peinado M, Sutherland RL, Clark SJ. Epigenetic deregulation across chromosome 2q14.2 differentiates normal cells from prostate cancer cells and provides a regional panel of DNA methylation prostate cancer biomarkers. Cancer Epidemiol Biomarkers Prev 2011; 20:148-59 *authors contributed equally to the work.
Nair S*, Coolen MW*, Stirzaker C*, Song JZ, Statham AL, Strbenac D, Robinson MD, Clark SJ. Comparison of Methyl-DNA Immunopreciptation (MeDIP) and Methyl-CpG Binding Domain (MBD) Protein Capture for Genome-wide DNA methylation Analysis Reveal CpG Sequence Coverage Bias. Epigenetics 2011; 6:34-44 *authors contributed equally to the work
Robinson MD, Stirzaker C, Statham AL, Coolen MW, Song JZ, Nair S, Strbenac D, Speed TP, Clark SJ. Evaluation of enrichment-based genome-wide DNA methylation data: effects of CpG density, amplification bias and copy number variation. Genome Res 2010; 20:1719-29
Coolen MW*, Stirzaker C*, Song JZ, Statham AL, Kassir Z, Moreno CS, Young AN, Varma V, Speed TP, Cowley M, Lacaze P, Kaplan W, Robinson MD, Clark SJ. Consolidation of the cancer genome into domains of repressive chromatin by long range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol 2010; 12:235-46. *authors contributed equally to the work
Clark SJ, Statham A, Stirzaker C, Molloy PL, Frommer M. DNA methylation: bisulphite modification and analysis. Nat Protoc 2006; 1:2353-64
Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet 2006; 38:540-9
Stirzaker C, Song JZ, Davidson B, Clark SJ. Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res 2004; 64:3871-7