Bone Biology Lab

Publications

An atlas of genetic influences on osteoporosis in humans and mice
Morris, J. A.; Kemp, J. P.; Youlten, S. E.; Laurent, L.; Logan, J. G.; Chai, R. C.; Vulpescu, N. A.; Forgetta, V.; Kleinman, A.; Mohanty, S. T.; Sergio, C. M.; Quinn, J.; Nguyen-Yamamoto, L.; Luco, A. L.; Vijay, J.; Simon, M. M.; Pramatarova, A.; Medina-Gomez, C.; Trajanoska, K.; Ghirardello, E. J.; Butterfield, N. C.; Curry, K. F.; Leitch, V. D.; Sparkes, P. C.; Adoum, A. T.; Mannan, N. S.; Komla-Ebri, D. S. K.; Pollard, A. S.; Dewhurst, H. F.; Hassall, T. A. D.; Beltejar, M. G.; andMe Research, Team; Adams, D. J.; Vaillancourt, S. M.; Kaptoge, S.; Baldock, P.; Cooper, C.; Reeve, J.; Ntzani, E. E.; Evangelou, E.; Ohlsson, C.; Karasik, D.; Rivadeneira, F.; Kiel, D. P.; Tobias, J. H.; Gregson, C. L.; Harvey, N. C.; Grundberg, E.; Goltzman, D.; Adams, D. J.; Lelliott, C. J.; Hinds, D. A.; Ackert-Bicknell, C. L.; Hsu, Y. H.; Maurano, M. T.; Croucher, P. I.; Williams, G. R.; Bassett, J. H. D.; Evans, D. M.; Richards, J. B.
NATURE GENETICS 51(2):258-266, 2019
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Kemp, J. P.; Morris, J. A.; Medina-Gomez, C.; Forgetta, V.; Warrington, N. M.; Youlten, S. E.; Zheng, J.; Gregson, C. L.; Grundberg, E.; Trajanoska, K.; Logan, J. G.; Pollard, A. S.; Sparkes, P. C.; Ghirardello, E. J.; Allen, R.; Leitch, V. D.; Butterfield, N. C.; Komla-Ebri, D.; Adoum, A. T.; Curry, K. F.; White, J. K.; Kussy, F.; Greenlaw, K. M.; Xu, C.; Harvey, N. C.; Cooper, C.; Adams, D. J.; Greenwood, C. M. T.; Maurano, M. T.; Kaptoge, S.; Rivadeneira, F.; Tobias, J. H.; Croucher, P. I.; Ackert-Bicknell, C. L.; Bassett, J. H. D.; Williams, G. R.; Richards, J. B.; Evans, D. M.
NATURE GENETICS 49(10):1468-1475, 2017
How to build personalized multi-omics comorbidity profiles
Moni, M. A.
; Lio, P.;
Front Cell Dev Biol 3:28, 2015
Osteoclast formation elicited by interleukin-33 stimulation is dependent upon the type of osteoclast progenitor
Eeles, D. G.
; Hodge, J. M.
; Singh, P. P.
; Schuijers, J. A.
; Grills, B. L.
; Gillespie, M. T.
; Myers, D. E.
; Quinn, J. M.;
MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:259-66, 2015
Elevated Bone Hardness Under Denosumab Treatment, With Persisting Lower Osteocyte Viability During Discontinuation
Jahn-Rickert, K.; Wolfel, E. M.; Jobke, B.; Riedel, C.; Hellmich, M.; Werner, M.; McDonald, M. M.; Busse, B.
Frontiers in Endocrinology 11:250, 2020
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
Liu, J.Z.; Hov, J.R.; Folseraas, T.; Ellinghaus, E.; Rushbrook, S.M.; Doncheva, N.T.; Andreassen, O.A.; Weersma, R.K.; Weismuller, T.J.; Eksteen, B.; Invernizzi, P.; Hirschfield, G.M.; Gotthardt, D.N.; Pares, A.; Ellinghaus, D.; Shah, T.; Juran, B.D.; Milkiewicz, P.; Rust, C.; Schramm, C.; Muller, T.; Srivastava, B.; Dalekos, G.; Nothen, M.M.; Herms, S.; Winkelmann, J.; Mitrovic, M.; Braun, F.; Ponsioen, C.Y.; Croucher, P.J.; Sterneck, M.; Teufel, A.; Mason, A.L.; Saarela, J.; Leppa, V.; Dorfman, R.; Alvaro, D.; Floreani, A.; Onengut-Gumuscu, S.; Rich, S.S.; Thompson, W.K.; Schork, A.J.; Naess, S.; Thomsen, I.; Mayr, G.; Konig, I.R.; Hveem, K.; Cleynen, I.; Gutierrez-Achury, J.; Ricano-Ponce, I.; van Heel, D.; Bjornsson, E.; Sandford, R.N.; Durie, P.R.; Melum, E.; Vatn, M.H.; Silverberg, M.S.; Duerr, R.H.; Padyukov, L.; Brand, S.; Sans, M.; Annese, V.; Achkar, J.P.; Boberg, K.M.; Marshall, H.U.; Chazouilleres, O.; Bowlus, C.L.; Wijmenga, C.; Schrumpf, E.; Vermeire, S.; Albrecht, M.; The UK-PSCSC Consortium; The International IBD Genetics Consortium; Rioux, J.D.; Alexander, G.; Bergquist, A.; Cho, J.; Schreiber, S.; Manns, M.P.; Farkkila, M.; Dale, A.M.; Chapman, R.W.; Lazaridis, K.N.; The International PSC Study Group; Franke, A.; Anderson, C.A.; Karlsen, T.H.
NAT GENET 45(6):670-5, 2013
Deep convolutional neural networks based ECG beats classification to diagnose cardiovascular conditions
Rashed-Al-Mahfuz, M.; Moni, M. A.; Lio, P.; Islam, S. M. S.; Berkovsky, S.; Khushi, M.; Quinn, J. M. W.
Biomedical Engineering Online 11(2):147-162, 2021
Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation
McDonald, M. M.; Morse, A.; Schindeler, A.; Mikulec, K.; Peacock, L.; Cheng, T.; Bobyn, J.; Lee, L.; Baldock, P. A.; Croucher, P. I.; Tam, P. P. L.; Little, D. G.
CALCIFIED TISSUE INTERNATIONAL 102(1):105-116, 2018
A Niche-Dependent Myeloid Transcriptome Signature Defines Dormant Myeloma Cells
Khoo, W. H.; Ledergor, G.; Weiner, A.; Roden, D. L.; Terry, R. L.; McDonald, M. M.; Chai, R. C.; De Veirman, K.; Owen, K. L.; Opperman, K. S.; Vandyke, K.; Clark, J. R.; Seckinger, A.; Kovacic, N.; Nguyen, A.; Mohanty, S. T.; Pettitt, J. A.; Xiao, Y.; Corr, A. P.; Seeliger, C.; Novotny, M.; Lasken, R. S.; Nguyen, T. V.; Oyajobi, B. O.; Aftab, D.; Swarbrick, A.; Parker, B.; Hewett, D. R.; Hose, D.; Vanderkerken, K.; Zannettino, A. C. W.; Amit, I.; Phan, T. G.; Croucher, P. I.
Blood 134(1):30-43, 2019
Inhibition of sclerostin systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats.
McDonald, M.M.; Morse, A.; Mikulec, K.; Peacock, L.; Yu, N.; Baldock, P.A.; Birke, O.; Liu, M.; Ke, H.Z.; Little, D.G.
JOURNAL OF ORTHOPAEDIC RESEARCH 30(10):1541-8, 2012
Targeting tumour-initiating cells with trail based combination therapy ensures complete and lasting eradication of multiple myeloma tumours in vivo.
Vitovski, S.; Chantry, A.D.; Lawson, M.A.; Croucher, P.I.
PLoS One 7(5):e35830, 2012
An Essential Physiological Role for MCT8 in Bone in Male Mice
Leitch, V. D.; Di Cosmo, C.; Liao, X. H.; O'Boy, S.; Galliford, T. M.; Evans, H.; Croucher, P. I.; Boyde, A.; Dumitrescu, A.; Weiss, R. E.; Refetoff, S.; Williams, G. R.; Bassett, J. H. D.
ENDOCRINOLOGY 158(9):3055-3066, 2017
Cancer Cell Dormancy in Metastasis
Summers, M. A.; McDonald, M. M.; Croucher, P. I.
Cold Spring Harbor Perspectives in Medicine 10(4) 2020
Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis
McDonald, M. M.; Morse, A.; Birke, O.; Yu, N. Y. C.; Mikulec, K.; Peacock, L.; Schindeler, A.; Liu, M.; Ke, H. Z.; Little, D. G.
JOURNAL OF ORTHOPAEDIC RESEARCH 36(4):1106-1113, 2018
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
Lawson, M.A.; McDonald, M.M.; Kovacic, N.; Khoo, W.H.; Terry, R.L.; Down, J.; Kaplan, K.; Paton-Hough, J.; Fellows, C.; Pettitt, J.A.; Dear, T.N.; Van Valckenborgh, E.; Baldock, P.A.; Rogers, M.J.; Eaton, C.L.; Vanderkerken, K.; Pettit, A.R.; Quinn, J.M.W.; Zannettino, A.C.W.; Phan, T.G.; Croucher, P.I
Nature Communications 6:8983, 2015
The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer
Wang, N.
; Reeves, K. J.
; Brown, H. K.
; Fowles, A. C.
; Docherty, F. E.
; Ottewell, P. D.
; Croucher, P. I.
; Holen, I.
; Eaton, C. L.;
J EXP CLIN CANC RES 34(1):124, 2015
COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disorders
Moni, M. A.; Lin, P. I.; Quinn, J. M. W.; Eapen, V.
Translational Psychiatry 11(1):160, 2021
An Activating Variant in CTNNB1 is Associated with a Sclerosing Bone Dysplasia and Adrenocortical Neoplasia
Peng, H.; Jenkins, Z. A.; White, R.; Connors, S.; Hunter, M. F.; Ronan, A.; Zankl, A.; Markie, D. M.; Daniel, P. B.; Robertson, S. P.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 105(3) 2020
Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective
Rahman, M. R.; Islam, T.; Zaman, T.; Shahjaman, M.; Karim, M. R.; Huq, F.; Quinn, J. M. W.; Holsinger, R. M. D.; Gov, E.; Moni, M. A.
GENOMICS 2020
Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors
Chai, R. C.; Vieusseux, J. L.; Lang, B. J.; Nguyen, C. H.; Kouspou, M. M.; Britt, K. L.; Price, J. T.
Molecular Oncology 11(5):567-583, 2017
Tumor cell dormancy and reactivation in bone: skeletal biology and therapeutic opportunities
Byrne, N.M., Summers, M.A. and McDonald, M.M.
JOURNAL OF BONE AND MINERAL RESEARCH PLUS 3(3):e10125, 2019
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength
Baud'huin, M.; Solban, N.; Cornwall-Brady, M.; Sako, D.; Kawamoto, Y.; Liharska, K.; Lath, D.; Bouxsein, M.L.; Underwood, K.W.; Ucran, J.; Kumar, R.; Pobre, E.; Grinberg, A.V.; Seehra, J.; Canalis, E.; Pearsall, R.S.; Croucher, P.I.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109(30):12207-12, 2012
An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion
Esapa, C. T.; Piret, S. E.; Nesbit, M. A.; Thomas, G. P.; Coulton, L. A.; Gallagher, O. M.; Simon, M. M.; Kumar, S.; Mallon, A. M.; Bellantuono, I.; Brown, M. A.; Croucher, P. I.; Potter, P. K.; Brown, S. D.; Cox, R. D.; Thakker, R. V.
JOURNAL OF BONE AND MINERAL RESEARCH PLUS 2(3):154-163, 2018
Protein kinase C inhibitor, GF109203X attenuates osteoclastogenesis, bone resorption and RANKL-induced NF-kappaB and NFAT activity
Yao, J.
; Li, J.
; Zhou, L.
; Cheng, J.
; Chim, S. M.
; Zhang, G.
; Quinn, J. M.
; Tickner, J.
; Zhao, J.
; Xu, J.;
JOURNAL OF CELLULAR PHYSIOLOGY 230(6):1235-42, 2015
A Network-Based Bioinformatics Approach to Identify Molecular Biomarkers for Type 2 Diabetes that Are Linked to the Progression of Neurological Diseases
Rahman, M. H.; Peng, S.; Hu, X.; Chen, C.; Rahman, M. R.; Uddin, S.; Quinn, J. M. W.; Moni, M. A.
International Journal of Environmental Research and Public Health 17(3):1035, 2020
The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest
Gascoyne, D. M.
; Spearman, H.
; Lyne, L.
; Puliyadi, R.
; Perez-Alcantara, M.
; Coulton, L.
; Fisher, S. E.
; Croucher, P. I.
; Banham, A. H.;
PLoS One 10(6):e0128513, 2015
Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo
Opperman, K. S.; Vandyke, K.; Clark, K. C.; Coulter, E. A.; Hewett, D. R.; Mrozik, K. M.; Schwarz, N.; Evdokiou, A.; Croucher, P. I.; Psaltis, P. J.; Noll, J. E.; Zannettino, A. C.
NEOPLASIA 21(8):777-787, 2019
Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer
Brown, H. K.; Allocca, G.; Ottewell, P. D.; Wang, N.; Brown, N. J.; Croucher, P. I.; Eaton, C. L.; Holen, I.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19(10) 2018
Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization
Horas, K.; Zheng, Y.; Fong-Yee, C.; Macfarlane, E.; Manibo, J.; Chen, Y.; Qiao, J.; Gao, M.; Haydar, N.; McDonald, M. M.; Croucher, P. I.; Zhou, H.; Seibel, M. J.
JOURNAL OF BONE AND MINERAL RESEARCH 34(9):1721-1732, 2019
Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone.
Ottewell, P.D.; Wang, N.; Meek, J.; Fowles, A.M.; Croucher, P.I.; Eaton, C.L.; Holen, I.
ENDOCRINE-RELATED CANCER 21(5):769-81, 2014
Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume
Morse, A.; Cheng, T. L.; Schindeler, A.; McDonald, M. M.; Mohanty, S. T.; Kneissel, M.; Kramer, I.; Little, D. G.
CALCIFIED TISSUE INTERNATIONAL 103(3):298-310, 2018
Denosumab compared with zoledronic acid on PFS in multiple myeloma: exploratory results of an international phase 3 study
Terpos, E.; Raje, N.; Croucher, P.; Garcia-Sanz, R.; Leleu, X.; Pasteiner, W.; Wang, Y.; Glennane, A.; Canon, J.; Pawlyn, C.
Blood Advances 5(3):725-736, 2021
Sclerostin antibody increases callus size and strength but does not improve fracture union in a challenged open rat fracture model
Morse, A.; McDonald, M. M.; Schindeler, A.; Peacock, L.; Mikulec, K.; Cheng, T. L.; Liu, M.; Ke, H. Z.; Little, D. G.
CALCIFIED TISSUE INTERNATIONAL 101(2):217-228, 2017
Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells
Faraahi, Z.; Baud'huin, M.; Croucher, P. I.; Eaton, C.; Lawson, M. A.
BONE 122:82-92, 2019
Berberine sulfate attenuates osteoclast differentiation through RANKL induced NF-κB and NFAT pathways
Zhou, L.
; Song, F.
; Liu, Q.
; Yang, M.
; Zhao, J.
; Tan, R.
; Xu, J.
; Zhang, G.
; Quinn, J. M.
; Tickner, J.
; Xu, J.;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16(11):27087-96, 2015
Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading
Morse, A.; Ko, F.; McDonald, M. M.; Lee, L.; Schindeler, A.; van der Meulen, M. C. H.; Little, D. G.
BONE 131:115054, 2020
The dormant cancer cell life cycle
Phan, T. G.; Croucher, P. I.
NATURE REVIEWS CANCER 20(7):398-411, 2020
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects
Medina-Gomez, C.; Kemp, J. P.; Trajanoska, K.; Luan, J.; Chesi, A.; Ahluwalia, T. S.; Mook-Kanamori, D. O.; Ham, A.; Hartwig, F. P.; Evans, D. S.; Joro, R.; Nedeljkovic, I.; Zheng, H. F.; Zhu, K.; Atalay, M.; Liu, C. T.; Nethander, M.; Broer, L.; Porleifsson, G.; Mullin, B. H.; Handelman, S. K.; Nalls, M. A.; Jessen, L. E.; Heppe, D. H. M.; Richards, J. B.; Wang, C.; Chawes, B.; Schraut, K. E.; Amin, N.; Wareham, N.; Karasik, D.; Van der Velde, N.; Ikram, M. A.; Zemel, B. S.; Zhou, Y.; Carlsson, C. J.; Liu, Y.; McGuigan, F. E.; Boer, C. G.; Bonnelykke, K.; Ralston, S. H.; Robbins, J. A.; Walsh, J. P.; Zillikens, M. C.; Langenberg, C.; Li-Gao, R.; Williams, F. M. K.; Harris, T. B.; Akesson, K.; Jackson, R. D.; Sigurdsson, G.; den Heijer, M.; van der Eerden, B. C. J.; van de Peppel, J.; Spector, T. D.; Pennell, C.; Horta, B. L.; Felix, J. F.; Zhao, J. H.; Wilson, S. G.; de Mutsert, R.; Bisgaard, H.; Styrkarsdottir, U.; Jaddoe, V. W.; Orwoll, E.; Lakka, T. A.; Scott, R.; Grant, S. F. A.; Lorentzon, M.; van Duijn, C. M.; Wilson, J. F.; Stefansson, K.; Psaty, B. M.; Kiel, D. P.; Ohlsson, C.; Ntzani, E.; van Wijnen, A. J.; Forgetta, V.; Ghanbari, M.; Logan, J. G.; Williams, G. R.; Bassett, J. H. D.; Croucher, P. I.; Evangelou, E.; Uitterlinden, A. G.; Ackert-Bicknell, C. L.; Tobias, J. H.; Evans, D. M.; Rivadeneira, F.
American Journal Of Human Genetics 102(1):88-102, 2018
Bioinformatics and machine learning methodologies to identify the effects of central nervous system disorders on glioblastoma progression
Rahman, M. H.; Rana, H. K.; Peng, S.; Hu, X.; Chen, C.; Quinn, J. M. W.; Moni, M. A.
BRIEFINGS IN BIOINFORMATICS 2021
Iodinated contrast does not alter clotting dynamics in acute ischemic stroke as measured by thromboelastography
McDonald, M. M.; Archeval-Lao, J. M.; Cai, C.; Peng, H.; Sangha, N.; Parker, S. A.; Wetzel, J.; Riney, S. A.; Cherches, M. F.; Guthrie, G. J.; Roper, T. C.; Kawano-Castillo, J. F.; Pandurengan, R.; Rahbar, M. H.; Grotta, J. C.;
STROKE 45(2):462-6, 2014
Optic disc swelling in acromicric and geleophysic dysplasia
Moey, L. H.; Flaherty, M.; Zankl, A.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A 179(9):1898-1901, 2019
Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes
Gregson, C. L.; Newell, F.; Leo, P. J.; Clark, G. R.; Paternoster, L.; Marshall, M.; Forgetta, V.; Morris, J. A.; Ge, B.; Bao, X.; Duncan Bassett, J. H.; Williams, G. R.; Youlten, S. E.; Croucher, P. I.; Davey Smith, G.; Evans, D. M.; Kemp, J. P.; Brown, M. A.; Tobias, J. H.; Duncan, E. L.
BONE 114:62-71, 2018
DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment
Hewett, D. R.; Vandyke, K.; Lawrence, D. M.; Friend, N.; Noll, J. E.; Geoghegan, J. M.; Croucher, P. I.; Zannettino, A. C. W.
NEOPLASIA 19(12):972-981, 2017
Bioinformatics and system biology approach to identify the influences of COVID-19 on cardiovascular and hypertensive comorbidities
Nashiry, A.; Sarmin Sumi, S.; Islam, S.; Quinn, J. M. W.; Moni, M. A.
BRIEFINGS IN BIOINFORMATICS 22(2):1387-1401, 2021
Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone
Owen, K. L.; Gearing, L. J.; Zanker, D. J.; Brockwell, N. K.; Khoo, W. H.; Roden, D. L.; Cmero, M.; Mangiola, S.; Hong, M. K.; Spurling, A. J.; McDonald, M.; Chan, C. L.; Pasam, A.; Lyons, R. J.; Duivenvoorden, H. M.; Ryan, A.; Butler, L. M.; Mariadason, J. M.; Giang Phan, T.; Hayes, V. M.; Sandhu, S.; Swarbrick, A.; Corcoran, N. M.; Hertzog, P. J.; Croucher, P. I.; Hovens, C.; Parker, B. S.
EMBO REPORTS 21(6):e50162, 2020
A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis
Gregson, C. L.; Bergen, D. J. M.; Leo, P.; Sessions, R. B.; Wheeler, L.; Hartley, A.; Youlten, S.; Croucher, P. I.; McInerney-Leo, A. M.; Fraser, W.; Tang, J. C.; Anderson, L.; Marshall, M.; Sergot, L.; Paternoster, L.; Davey Smith, G.; Consortium, Aogc; Brown, M. A.; Hammond, C.; Kemp, J. P.; Tobias, J. H.; Duncan, E. L.
JOURNAL OF BONE AND MINERAL RESEARCH 35(1):92-105, 2020
A machine learning model to identify early stage symptoms of SARS-Cov-2 infected patients
Ahamad, M. M.; Aktar, S.; Rashed-Al-Mahfuz, M.; Uddin, S.; Lio, P.; Xu, H.; Summers, M. A.; Quinn, J. M. W.; Moni, M. A.
EXPERT SYSTEMS WITH APPLICATIONS 160:113661, 2020
Adipose, Bone, and Myeloma: Contributions from the Microenvironment
McDonald, M. M.; Fairfield, H.; Falank, C.; Reagan, M. R.
CALCIFIED TISSUE INTERNATIONAL 100(5):433-448, 2017
Genetic Profiling and Comorbidities of Zika Infection
Moni, M. A.; Lio, P.
JOURNAL OF INFECTIOUS DISEASES 216(6):703-712, 2017
Genetic effects of welding fumes on the progression of neurodegenerative diseases
Rana, H. K.; Akhtar, M. R.; Ahmed, M. B.; Lio, P.; Quinn, J. M. W.; Huq, F.; Moni, M. A.
NEUROTOXICOLOGY 71:93-101, 2019
A computational approach to identify blood cell-expressed Parkinson's disease biomarkers that are coordinately expressed in brain tissue
Moni, M. A.; Rana, H. K.; Islam, M. B.; Ahmed, M. B.; Xu, H.; Hasan, M. A. M.; Lei, Y.; Quinn, J. M. W.
COMPUTERS IN BIOLOGY AND MEDICINE 113:103385, 2019
The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis
Fairfield H, Falank C, Harris E, Demambro V, McDonald M, Pettitt JA, Mohanty ST, Croucher P, Kramer I, Kneissel M, Rosen CJ, Reagan MR.
JOURNAL OF CELLULAR PHYSIOLOGY 233(2):1156-1167, 2018
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density
Swan, A. L.; Schutt, C.; Rozman, J.; Del Mar Muniz Moreno, M.; Brandmaier, S.; Simon, M.; Leuchtenberger, S.; Griffiths, M.; Brommage, R.; Keskivali-Bond, P.; Grallert, H.; Werner, T.; Teperino, R.; Becker, L.; Miller, G.; Moshiri, A.; Seavitt, J. R.; Cissell, D. D.; Meehan, T. F.; Acar, E. F.; Lelliott, C. J.; Flenniken, A. M.; Champy, M. F.; Sorg, T.; Ayadi, A.; Braun, R. E.; Cater, H.; Dickinson, M. E.; Flicek, P.; Gallegos, J.; Ghirardello, E. J.; Heaney, J. D.; Jacquot, S.; Lally, C.; Logan, J. G.; Teboul, L.; Mason, J.; Spielmann, N.; McKerlie, C.; Murray, S. A.; Nutter, L. M. J.; Odfalk, K. F.; Parkinson, H.; Prochazka, J.; Reynolds, C. L.; Selloum, M.; Spoutil, F.; Svenson, K. L.; Vales, T. S.; Wells, S. E.; White, J. K.; Sedlacek, R.; Wurst, W.; Lloyd, K. C. K.; Croucher, P. I.; Fuchs, H.; Williams, G. R.; Bassett, J. H. D.; Gailus-Durner, V.; Herault, Y.; Mallon, A. M.; Brown, S. D. M.; Mayer-Kuckuk, P.; Hrabe de Angelis, M.; Consortium, Impc
PLOS GENET 16(12):e1009190, 2020
Sclerostin Antibody Augments the Anabolic Bone Formation Response in a Mouse Model of Mechanical Tibial Loading
Morse, A.; Schindeler, A.; McDonald, M. M.; Kneissel, M.; Kramer, I.; Little, D. G.
JOURNAL OF BONE AND MINERAL RESEARCH 33(3):486-498, 2018
Genetic effects of welding fumes on the development of respiratory system diseases
Rana, H. K.; Akhtar, M. R.; Islam, M. B.; Ahmed, M. B.; Lio, P.; Quinn, J. M. W.; Huq, F.; Moni, M. A.
COMPUTERS IN BIOLOGY AND MEDICINE 108:142-149, 2019
Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma
McDonald, M. M.; Reagan, M. R.; Youlten, S. E.; Mohanty, S. T.; Seckinger, A.; Terry, R. L.; Pettitt, J. A.; Simic, M. K.; Cheng, T. L.; Morse, A.; Le, L. M. T.; Abi-Hanna, D.; Kramer, I.; Falank, C.; Fairfield, H.; Ghobrial, I. M.; Baldock, P. A.; Little, D. G.; Kneissel, M.; Vanderkerken, K.; Bassett, J. H. D.; Williams, G. R.; Oyajobi, B. O.; Hose, D.; Phan, T. G.; Croucher, P. I.
Blood 129(26):3452-3464, 2017
CytoCom: a Cytoscape app to visualize, query and analyse disease comorbidity networks
Moni, M.A.
; Xu, H.
; Lio, P.;
Bioinformatics 31(6):969-71, 2015
Defective DNA Polymerase alpha-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism
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