Bone Biology Lab

Selected Publications

Morris J, Kemp J, Youlten S, Logan J, Chai R, Vulpescu N, Forgetta V, Kleinman A, Mohanty S, Sergio M, Medina-Gomez C, Trajanoska K, Quinn J, Ghirardello E, Butterfield N, Curry K, Leitch V, Sparkes P, Laurent L, Adoum AT, Mannan N, Komla-Ebri D, Pollard A, Dewhurst H, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani E, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Ackert-Bicknell C, Kiel D, Tobias J, Gregson C, Harvey N, Adams D, Lelliott C, Hinds D, Hsu YH, M. An Atlas of Human and Murine Genetic Influences on Osteoporosis. Nat Genet. 2018 doi: 10.1038/s41588-018-0302-x

John P Kemp, John A Morris, Carolina Medina-Gomez5, Vincenzo Forgetta, Nicole M Warrington, Scott E Youlten, Jie Zheng, Celia L Gregson, Elin Grundberg, Katerina Trajanoska, John G Logan, Andrea S Pollard, Penny C Sparkes, Elena J Ghirardello, Rebecca Allen, Victoria D Leitch, Natalie C Butterfield, Davide Komla-Ebri, Anne-Tounsia Adoum, Katharine F Curry, Jacqueline K White, Fiona Kussy, Keelin M Greenlaw, Changjiang Xu, Nicholas C Harvey, Cyrus Cooper, David J Adams, Celia M T Greenwood, Matthew T Maurano, Stephen Kaptoge, Fernando Rivadeneira, Jonathan H Tobias, Peter I Croucher, Cheryl L Ackert-Bicknell, J H Duncan Bassett, Graham R Williams, J Brent Richards & David M Evans. Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nat Genet. 2017 Sep 4. doi: 10.1038/ng.3949. Epub 2017 Sep 4.

McDonald MM, Reagan MR, Youlten SE, Mohanty ST, Seckinger A, Terry RL, Pettitt JA, Simic MK, Cheng TL, Morse A, Le LMT, Abi-Hanna D, Kramer I, Falank C, Fairfield H, Ghobrial IM, Baldock PA, Little DG, Kneissel M, Vanderkerken K, Bassett JHD, Williams GR, Oyajobi BO, Hose D, Phan TG, Croucher PI. Inhibiting the osteocyte specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. 2017 Jun 29;129(26):3452-3464. doi: 10.1182/blood-2017-03-773341. Epub 2017 May 17.

Croucher PI, McDonald MM, Martin TJ. Bone metastasis: the importance of the neighbourhood. (2016) Nat Rev Cancer. May 25;16(6):373-86.

Lawson MA, McDonald MM, Kovacic N, Hua Khoo W, Terry RL, Down J, Kaplan W, Paton-Hough J, Fellows C, Pettitt JA, Neil Dear T, Van Valckenborgh E, Baldock PA, Rogers MJ, Eaton CL, Vanderkerken K, Pettit AR, Quinn JM, Zannettino AC, Phan TG, Croucher PI. Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. (2015) Nat Commun. Dec 3;6:8983.

Wang N., Docherty F., Brown H.K., Reeves K., Fowles A., Lawson M., Ottewell P.D., Holen I., Croucher P.I., Eaton C.L. Mitotic quiescence, but not unique "stemness", marks the phenotype of bone metastasis-initiating cells in prostate cancer. FASEB J article fj.14-266379. Published online April 17, 2015.

Esapa C., Hannan F., Babinsky V., Potter P., Thomas G., Croucher P., Brown M., Brown S., Cox R. N-ethyl-N-nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. PloS One. DOI:10.1371/journal.pone.0122650 April 10, 2015.

Croucher P.I., Parker B.S., Corcoran N., Rogers M.J.  Bone turnover markers and prostate cancer: Not just a measure of bone disease? Eur Urol. 2014 Nov 11. pii: S0302-2838(14)01157-9. doi: 10.1016/j.eururo.2014.10.041. [Epub ahead of print].

Wang N., Docherty F.E., Brown H.K., Reeves K.J., Fowles A.C., Ottewell P.D., Dear T.N., Holen I., Croucher P.I., Eaton C.L. (2014). Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis - evidence from in vivo models. J Bone Miner Res, 29:2688-2696.

Ottewell P.D., Wang N., Meek J., Fowles A.M., Croucher P.I., Eaton C.L., Holen I. (2014). Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone. Endocr Relat Cancer, 21:769-781.

Ottewell, P.D., Wang, N., Reeves, K.J., Fowles, C.A.M., Croucher, P.I., Eaton, C.L., Holen, I (2014).  Zoledronic acid has differential anti-tumour activity in the pre-and post-menopausal bone microenvironment in vivo. Clin Cancer Res, 20:2922-2932.

Junankar, S., Shay, G., Jurczyluk, J., Ali, N., Down, J., Pocock, N., Parker, A., Nguyen, A., Sun, S., Kashemirov, B., McKenna, C.E., Croucher, P.I., Swarbrick, A., Weilbaecher, K., Phan, T.G., Rogers, M.J. Real-time intravital imaging establishes tumour-associated macrophages as the extraskeletal target of bisphosphonate action in cancer. Cancer Discovery. 2015 Jan;5(1):35-42. doi: 10.1158/2159-8290.CD-14-0621.

Bassett, J.H., Boyde, A., Zikmund, T., Evans, H., Croucher, P.I., Zhu, X., Park, J.W., Cheng, S.Y., Williams, G.R. Thyroid hormone receptor alpha mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice. Endocrinology. 2014; 155(9):3699-712.

Kassen, D., Moore, S., Percy, L., Herledan, G., Bounds, D., Rodriguez-Justo, M., Croucher, P., Yong, K. The bone marrow stromal compartment in multiple myeloma patients retains capability for osteogenic differentiation in vitro: defining the stromal defect in myeloma. Br J Haematol. 2014; 167(2):194-206.

Bentley, L., Esapa, C.T., Nesbit, M.A., Head, R.A., Evans, H., Lath, D., Scudamore, C.L., Hough, T.A., Podrini, C., Hannan, F.M., Fraser, W.D., Croucher, P.I., Brown, M.A., Brown, S.D., Cox, R.D., Thakker, R.V. (2014) An N-ethyl-N-nitrosourea induced Corticotropin releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess. Endocrinology, 155(3):908-922.

Kovacic, N., Croucher, P.I., McDonald, M.M. (2014) Signaling Between Tumor Cells and the Host Bone Marrow Microenvironment. Calcified Tissue International, 94(1):125-139.

Xu, S., De Veirman, K., Evans, H., Santini, G.C., Vande Broek, I., Leleu, X., De Becker, A., Van Camp, B., Croucher, P., Vanderkerken, K., Van Riet, I. (2013) Effect of the HDAC inhibitor vorinstat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo. Acta Pharmacologica Sinica, 34:699-709.

Piret, S.E., Esapa, C.T., Gorvin, C.M., Head, R., Loh, N.Y., Devuyst, O., Thomas, G., Brown, S.D., Brown, M., Croucher P., Cox, R., Thakker, R.V. (2012) A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation. PLoS One, 7:e45217.

Esapa, C.T., Head, R.A., Jeyabalan, J., Evans, H., Hough, T.A. Cheeseman, M.T., McNally, E.G. Carr, A.J., Thomas, G.P., Brown, M.A., Croucher, P.I., Brown, S.D., Cox, R.D., Thakker, R.V. A mouse an N-ethyl-n-nitrosourea (ENU) induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis. PLoS One, 2012; 7:e43205.

Buckle, C.H., De Leenheer, E., Lawson, M.A., Yong, K, Rabin, N., Perry, M., Vanderkerken, K., Croucher P.I. Soluble rank ligand produced by myeloma cells causes generalized bone loss in multiple myeloma. PLoS One, 2012; 7:e41127.

Bassett, J.H.D., Gogakos, A., White, J.K., Evans, H., Jacques, R.M., Van der Spek, A., Sanger Mouse Genetics Project, Ramirez-Solis, R., Ryder, E., Sunter, D., Boyde, A., Campbell, M.J., Croucher, P.I., Williams, G.R. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genetics. 2012; 8:e1002858.

Baud’huin, M., Nicolas Solban, N., Cornwall-Brady, M., Sako, D., Kawamoto, Y., Liharska, K., Lath, D., Bouxsein, M.L., Underwood, K.W., Ucran, J., Kumar, R., Pobre, E.G., Grinberg, A.V., Seehra, J., Canalis, E., Pearsall, R.S., Croucher, P.I. A Soluble Alk3/BMPR1A Receptor Increases Bone Mass and Bone Strength.  PNAS USA. 2012; 109:12207-12212.

Bassett, J.H., Logan, J.G., Boyde, A., Cheung, M.S., Evans, H., Croucher, P., Sun, X.Y., Xu, S., Murata, Y., Williams, G.R. Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function. Endocrinology. 2012; 153:3537-3548.

Karunaratne, A., Esapa, C., Hiller, J., Boyde, A., Head, R., Bassett, J., Terrill, N., Williams, G., Brown, M., Croucher, P., Brown, S., Cox, R., Barber, A., Thakker, R., Gupta, H. Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron x-ray scattering and backscattered electron imaging.  J Bone Miner Res, 2011; 27(4):876-890.

Esapa, C., Hough, T., Testori, S., Head, R., Crane, E., Chan, C., Evans, H., Bassett, J., Tylzanowski, P., McNally, E., Carr, A., Boyde, A., Howell, P., Clark, A., Williams, G., Brown, M., Croucher, P., Nesbit, M., Brown, S., Cox, R., Cheeseman, M., Thakker, R. A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation. Journal of Bone & Mineral Research, 2011; 27: 413-428.

Gambardella, A., Nagaraju, C.K., O’Shea, P.J., Mohanty, S.T., Kottam, L., Pilling, J., Sullivan, M., Djerbi, M., Koopman, W., Croucher, P.I., Bellantuono, I. Glycogen synthase kinase-3a/b inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage.  J Bone Miner Res, 2011; 26(4):811-821.

Chantry, A.D., Heath, D., Mulivor, A., Pearsall, R.S., Baud’huin, M., Coulton, L., Evans, H., Abdul, N., Werner, E.D., Bouxsein,M.L., Key, M.L., Arnett, T.R., Seehra, J., Vanderkerken, K., Croucher, P.I. Inhibiting activin-A signaling stimulates bone formation and prevents cancer induced bone destruction in vivo. J Bone Miner Res, 2010; 25:2357-2370.

Bassett, J.H., Boyde, A., Howell, P.G., Bassett, R.H., Galliford, T.M., Archanco, M., Evans, H., Lawson, M.A., Croucher, P., St Germain, D.L., Galton, V.A., Wiliams, G.R. Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts.  Proceedings of the National Academy of Sciences USA, 2010; 107:7604-7609.


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