Mitochondrial Metabolism and Ageing

Publications

Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation
Dent, J. R.; Martins, V. F.; Svensson, K.; LaBarge, S. A.; Schlenk, N. C.; Esparza, M. C.; Buckner, E. H.; Meyer, G. A.; Hamilton, D. L.; Schenk, S.; Philp, A.
Molecular Metabolism 6(12):1574-1584, 2017
Molecular regulation of human skeletal muscle protein synthesis in response to exercise and nutrients: a compass for overcoming age-related anabolic resistance.
Hodson, N. West, DWD. Philp, A. Burd, NA. Moore, DR
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 317(6):C1061-C1078, 2019
The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
Hodson, N.; Philp, A.
EXERCISE AND SPORT SCIENCES REVIEWS 47(1):46-53, 2018
Graded reductions in preexercise muscle glycogen impair exercise capacity but do not augment skeletal muscle cell signaling: implications for CHO periodization
Hearris, M. A.; Hammond, K. M.; Seaborne, R. A.; Stocks, B.; Shepherd, S. O.; Philp, A.; Sharples, A. P.; Morton, J. P.; Louis, J. B.
JOURNAL OF APPLIED PHYSIOLOGY 126(6):1587-1597, 2019
Characterisation of L-Type Amino Acid Transporter 1 (LAT1) Expression in Human Skeletal Muscle by Immunofluorescent Microscopy
Hodson, N.; Brown, T.; Joanisse, S.; Aguirre, N.; West, D. W. D.; Moore, D. R.; Baar, K.; Breen, L.; Philp, A.
Nutrients 10(1):pii: E23, 2017
Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years
Pollock, R. D.; O'Brien, K. A.; Daniels, L. J.; Nielsen, K. B.; Rowlerson, A.; Duggal, N. A.; Lazarus, N. R.; Lord, J. M.; Philp, A.; Harridge, S. D. R.
AGING CELL 17(2):e12735, 2018
Postexercise skeletal muscle signaling responses to moderate- to high-intensity steady-state exercise in the fed or fasted state
Stocks, B.; Dent, J. R.; Ogden, H. B.; Zemp, M.; Philp, A.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 316(2):E230-E238, 2019
Reductions in skeletal muscle mitochondrial mass are not restored following exercise training in patients with chronic kidney disease
Watson, E. L.; Baker, L. A.; Wilkinson, T. J.; Gould, D. W.; Graham-Brown, M. P. M.; Major, R. W.; Ashford, R. U.; Philp, A.; Smith, A. C.
FASEB JOURNAL 34(1):1755-1767, 2020
PPARalpha-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia
O'Brien, K. A.; Horscroft, J. A.; Devaux, J.; Lindsay, R. T.; Steel, A. S.; Clark, A. D.; Philp, A.; Harridge, S. D. R.; Murray, A. J.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1865(4):844-853, 2019
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD(+) Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Elhassan, Y. S.; Kluckova, K.; Fletcher, R. S.; Schmidt, M. S.; Garten, A.; Doig, C. L.; Cartwright, D. M.; Oakey, L.; Burley, C. V.; Jenkinson, N.; Wilson, M.; Lucas, S. J. E.; Akerman, I.; Seabright, A.; Lai, Y. C.; Tennant, D. A.; Nightingale, P.; Wallis, G. A.; Manolopoulos, K. N.; Brenner, C.; Philp, A.; Lavery, G. G.
Cell Reports 28(7):1717-1728 e6, 2019
Molecular regulation of human skeletal muscle protein synthesis in response to exercise and nutrients: a compass for overcoming age-related anabolic resistance
Hodson, N.; West, D. W. D.; Philp, A.; Burd, N. A.; Moore, D. R.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 317(6):C1061-C1078, 2019
One Week of Step Reduction Lowers Myofibrillar Protein Synthesis Rates in Young Men
Shad, B. J.; Thompson, J. L.; Holwerda, A. M.; Stocks, B.; Elhassan, Y. S.; Philp, A.; van Loon, L. J. C.; Wallis, G. A.
Med Sci Sports 51(10):2125-2134, 2019
Translocation and protein complex co-localization of mTOR is associated with postprandial myofibrillar protein synthesis at rest and after endurance exercise
Abou Sawan, S.; van Vliet, S.; Parel, J. T.; Beals, J. W.; Mazzulla, M.; West, D. W. D.; Philp, A.; Li, Z.; Paluska, S. A.; Burd, N. A.; Moore, D. R.
Physiological Reports 6(5):e13628, 2018