Clinical Diabetes, Appetite and Metabolism Lab

Selected Publications

Snaith JR, Holmes-Walker DJ, Greenfield JR. Reducing Type 1 Diabetes Mortality: role for adjunctive therapies? Trends in Endocrinology and Metabolism Solicited review. 31:150-164 (2020).

Snaith JR, Holmes-Walker DJ, Greenfield JR. Risk factors for cardiovascular disease (CVD) in adults with type 1 diabetes: findings from Prospective Real-Life T1D exchange Registry (Letter to the Editor).  J Clin Endocrinol Metab. (2020).

Harari A, Coster AC, Jenkins A, Xu A, Greenfield JR, Harats D, Shaish A, Samocha-Bonet D. Obesity and insulin resistance are inversely associated with serum and adipose tissue carotenoid concentrations in Adults.   J Nutr. 150: 38-46 (2020).

Smith FC, Stocker SL, Danta M, Carland JE, Kumar SS, Liu Z, Greenfield JR, Braithwaite HE, Cheng TS, Graham GG, Williams KM, Day RO.  The safety and pharmacokinetics of metformin in patients with chronic liver disease.  Aliment Pharmacol Ther. 51: 565-575 (2020).

Lasschuit JWJ, Greenfield JR, Tonks KT.  High Risk Foot Service reduces number of Emergency Department presentations and length of stay.  Diabetes Metab. 46(3): 252-255 (2020).

Milder TY, Day RO, Stocker SL, Greenfield JR.  Should the cardio-protective properties of sodium-glucose cotransporter 2 inhibitors dictate therapeutic decision-making in patients with type 2 diabetes.  Intern Med J. 50: 645-646 (2020).

Mortimer B, Naganur VD, Satouris P, Greenfield JR, Torpy DJ, Rushworth RL.  Acute illness in patients with concomitant Addison's disease and type 1 diabetes mellitus: Increased incidence of hypoglycaemia and adrenal crisesClin Endocrinol (Oxf).  May 12. doi: 10.1111/cen.14219 (2020).

Lasschuit JWJ, Center JR, Greenfield JR, Tonks KT. Comparison of calcaneal quantitative ultrasound and bone densitometry parameters as fracture risk predictors in type 2 diabetes mellitus.  Diabet Med. 46: 252-255 (2020).   

Martin C, Ait Boudaoud A, Poghosyan T, Zhu J, Larger E, Greenfield JR, Czernichow S, Rives-Lange C, Carette C. Prevalence of anti-GAD and IA2 autoantibodies in a French cohort of patients with diabetes eligible for bariatric surgery. Diabetes Metab S1262-3636: 30190-9 (2019).

Patel S, Chin V, Greenfield JR. Durvalumab-induced diabetic ketoacidosis followed by hypothyroidism.  Endocrinol Diabetes Metab Case Rep. 19-0098 (2019).

Lenders NF, Greenfield JR. Urinary steroid profiling in diagnostic evaluation of an unusual adrenal mass. Endocrinol Diabetes Metab Case Rep. 19-0090 (2019).

Milder TY, Stocker SL, Samocha-Bonet D, Day RO*, Greenfield JR*. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes – cardiovascular and renal benefits in patients with chronic kidney disease. Eur J Clin Pharmacol. 75:1481-1490 (2019).

Greenfield JR, Carette C, Czernichow S. Comment on: Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults. N Engl J Med 381:e17 (2019).

Abdel Shaheed C, Carland JE, Graham GG, Stocker SL, Smith G, Hicks M, Williams KM, Furlong T, MacDonald P, Greenfield JR, Smith FC, Chowdhury G, Day RO. Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis. Br J Clin Pharmacol. Br J Clin Pharmacol. 85: 2772-2783 (2019).

Cehic MG, Muir CA, Greenfield JR, Hayward C, Jabbour A, Keogh A, Kotlyar E, Muthiah K, Macdonald PS. Efficacy and safety of empagliflozin in the management of diabetes mellitus in heart transplant recipients. Transplant Direct. 5: e450 (2019).

Milder TY, Stocker SL, Abdel Shaheed C, McGrath-Cadell L, Samocha-Bonet D, Greenfield JR, Day RO. Combination therapy with an SGLT2 inhibitor as initial treatment for type 2 diabetes: a systematic review and meta-Analysis. J Clin Med. 8: E45 (2019).

Snaith JR, Holmes-Walker J, Girgis C, Greenfield JR. Excess mortality and cardiovascular disease in type 1 diabetes: is insulin resistance an under-recognised culprit? Lancet (correspondence) 393: 984-985 (2019).

Snaith JR, Holmes-Walker J, Greenfield JR. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care (comment) 42: e135-136 (2019).

Tang A, Coster A, Tonks K, Heilbronn L, Pocock N, Purtell L, Govendir M, Blythe M, Zhang J, Xu A, Chisholm DJ, Johnson N, Greenfield JR*, Samocha-Bonet D*. Longitudinal changes in insulin resistance in normal weight, overweight and obese individuals. J Clin Med. 8:623 (2019).

Taylor J, Campbell LV, Greenfield JR. High diabetes prevalence and insulin medication errors in hospital patients (Author reply). Int Med J (correspondence) 49: 552 (2019).

Isaacs M, Costin M, Bova R, Barrett HL, Heffernan D, Samaras K, Greenfield JR. Management of amiodarone-induced thyrotoxicosis at a cardiac transplantation centre. Frontiers 9: 482 (2018). 

Kumar S, McManus H, Radovich T, Greenfield JR, Viardot A, Williams KM, Croni P, Day RO. Interrogation of a longitudinal, national pharmacy claims dataset to explore factors that predict the need for add-on therapy in older and socioeconomically disadvantaged Australians with type 2 diabetes mellitus patients (T2DM) Eur J Clin Pharmacol 74:1327–1332 (2018).

Lasschuit JWJ, Greenfield JR, Tonks KT. High risk service reduces number of Emergency Department presentations and length of stay. Diabetes Metab  S1262 (2018).

Taylor J, Zhang, L, Campbell LV, Greenfield JR. High diabetes prevalence and insulin medication errors in hospital patients. Int Med J 48: 1529-1532 (2018).

Du TY, Piscitelli D, Ahmad S, Trahair LG, Greenfield JR, Samocha-Bonet D, Rayner CK, Horowitz M, Jones KL. Effects of glutamine on gastric emptying of low- and high-nutrient drinks in healthy young subjects – impact on glycaemia Nutrients 10: E739 (2018).

Samocha-Bonet D, Debs S, Greenfield JR. Prevention and treatment of type 2 diabetes – a pathophysiological-based approach. Trends Endocrinol Metab 29: 370-379 (2018).

Fazekas-Lavu M, Reyes M, Malouf M, Plit M, Havyrk A, Campbell LV, Center JR, Glanville AR, Greenfield JR. High prevalence of diabetes before and after lung transplantation: target for improving outcome. Int Med J 48: 916-924 (2018).

Cehic MG, Nundell N, Greenfield JR, MacDonald PS. Management strategies for post-transplant diabetes mellitus after heart transplantation: a review. J Transplant (2018).

Fazakerley DJ, Chaudhuri R, Yang P, Maghzal GJ, Thomas KC, Krycer JR, Humphrey SJ, Parker BL, Fisher-Wellman KH, Meoli CC, Hoffman NJ, Diskin C, Burchfield JG, Cowley MJ, Kaplan W, Modrusan Z, Kolumam G, Yang JY, Chen DL, Samocha-Bonet D, Greenfield JR, Hoehn KL, Stocker R, James DE. Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. Elife (on-line, Feb 6; 7. pii: e32111 2018).

Ma C, Tonks K, Center JR, Samocha-Bonet D, Greenfield JR. Complex interplay among adiposity, insulin resistance and bone health. Clin Obes 8: 131-139 (2018).

Clarke J, Proudfoot J, Vatiliotis V, Verge C, Holmes-Walker DJ, Campbell L, Wilhelm K, Moravac C, Indu PS, Bridgett M.  Attitudes towards mental health, mental health research and digital interventions by young adults with type 1 diabetes: A qualitative analysis.  Health Expect. 2018 doi: 10.1111/hex.12662. [Epub ahead of print]

Kozan P, Blythe JC, Greenfield JR, Samocha-Bonet D. The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans-A Randomized Placebo-Controlled Study. Nutrients. 2017 9(8). pii: E861.

Isaacs M1, Tonks KT1,2,3, Greenfield JR1,2,3. Euglycaemic diabetic ketoacidosis in patients using sodium-glucose co-transporter 2 inhibitors. Intern Med J. 2017 47(6):701-704.

Lee P, Swarbrick MM, Greenfield JR.   The Sum of All Browning in FGF21 Therapeutics.  Cell Metab. 2015 21:795-6.

Lee P and Greenfield JR. Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans. Molecular and Cellular Endocrinology. 2015 Dec 15;418 Pt 2:184-90. Review.

Samocha-Bonet D, Chisholm DJ, Gribble FM, Holst JJ, Greenfield JR. L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients. Nutrients. 2015 Mar 24;7 (4):2101-8.

Lee P, Greenfield JR. What is the optimal bone-preserving strategy for patients with Addison’s disease? Clin Endocrinol (Oxf). 2015 Aug 83(2):157-61.

Kozusko K, Tsang VHM, Bottomley W, Cho YH, Gandotra S, Mimmack ML, Lim K, Isaac I, Patel S, Saudek V, O'Rahilly S, Srinivasan S, Greenfield JR, Barroso I, Campbell LV, DB Savage. Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. Diabetes. 2015 64: 299-310.

Samocha-Bonet D, Chisholm DJ, Gribble FM, Coster AC, Carpenter KH, Jones GR, Holst JJ, Greenfield JR. Glycemic Effects and Safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. PLoS One. 2014 20: e113366.

Kozusko K, Tsang VHM, Bottomley W, Cho YH, Gandotra S, Mimmack ML, Lim K, Isaac I, Patel S, Saudek V, O'Rahilly S, Srinivasan S, Greenfield JR, Barroso I, Campbell LV, DB Savage. Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. Diabetes. 2014.

Heilbronn LK, Campbell LV, Xu, A, Samocha Bonet D. Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased in acute overfeeding in healthy humans. PLOS-One 2013; 8:e78864.

Jenkins A, Batterham M, Samocha-Bonet D, Tonks K, Greenfield JR, Campbell LV. Segregation of a latent high adiposity phenotype in families with a history of type 2 diabetes mellitus implicates rare obesity-susceptibility genetic variants with large effects in diabetes-related obesity. PLOS One 2013; 8:e70435.

Peake P, Colagiuri S, Campbell LV and Shen Y. Paradoxically low levels of total and HMW adiponectin in relation to metabolic parameters in a Tongan population. ISRN Endocrinology 2013; 2013:873507.

Singer J, Trollor JN, Crawford J, O'Rourke MF, Baune BT, Brodaty H, Samaras K, Kochan NA, Campbell L, Sachdev PS, Smith E. The Association between Pulse Wave Velocity and Cognitive Function: The Sydney Memory and Ageing Study.  PLoS One. 2013; 8:e61855.

Greenfield JR, Chisholm DJ. How sweet it is: intestinal sweet taste receptors in type 2 diabetes. Diabetes 2013; 62:3336-3337.

Hocking SL, Samocha-Bonet D, Milner K-L, Greenfield JR, Chisholm DJ. Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots. Endocr Rev 2013; 34: 463-500.

Chang J, Wu T, Greenfield JR, Samocha-Bonet D, Horowitz M, Rayner CK. Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion and antropyloroduodenal motility in health and type 2 diabetes. Diabetes Care 2013; 36: 2262-2265.

Tonks KT, Ng Y, Miller S,Coster ACF, Samocha-Bonet D, Iseli TJ, Xu A, Patrick P, Yang JYH, Junutula JR, Modrusan Z, Kolumam G, Stöckli J, Chisholm DJ, James DE*,Greenfield JR* (*equal last authors).Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects. Diabetologia. 2013; 56: 875-85.

Greenfield JR, Samaras K, Campbell LV. Sugar-Sweetened Beverages and Genetic Risk of Obesity (Letter).  N Engl J Med. 2013; 368:285.

Purtell L, Jenkins A, Viardot A, Herzog H, Sainsbury A, Smith A, Loughnan G, Steinbeck K, Campbell LV, Sze L. Postprandial cardiac autonomic function in Prader-Willi syndrome.  Clin Endocrinol (Oxf). 2013; 79(1):128-33.

Samocha-Bonet D, Campbell LV, Mori TA, Croft KD, Greenfield JR, Turner N, Heilbronn LK.  Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans.  PLoS One. 2012; 7(5) e36320.

Samocha-Bonet D, Chisholm DJ, Tonks K, Campbell LV, Greenfield JR. Insulin-sensitive obesity in humans - a 'favorable fat' phenotype? Trends Endocrinol Metab. 2012; 23:116-24.

Trollor JN, Smith E, Agars E, Kuan SA, Baune BT, Campbell LV, Samaras K, Crawford J, Lux O, Kochan NA, Brodaty H, Sachdev P. The association between systemic inflammation and cognitive performance in the elderly: The Sydney Memory and Ageing Study. Age (Dordr). 2012; 34:1295-308.

Wilhelm K, Gillis I, Reddy J, Mitchell PB, Campbell L, Dobson-Stone C, Pierce KD, Schofield PR. Association between serotonin transporter promoter polymorphisms and psychological distress in a diabetic population. Psychiatry Res.  2012; 200:343-8.

Purtell L, Sze L, Loughnan G, Smith E, Herzog H, Sainsbury A, Steinbeck K, Campbell LV, Viardot A. In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels. Neuropeptides. 2011; 45:301-7.

Ho-Pham LT, Campbell LV, Nguyen TV. More on body fat cutoff points. Mayo Clin Proc. 2011; 86:584.

Sze L, Purtell L, Jenkins A, Loughnan G, Smith E, Herzog H, Sainsbury A, Steinbeck K, Campbell LV, Viardot A. Effects of a Single Dose of Exenatide on Appetite, Gut Hormones, and Glucose Homeostasis in Adults with Prader-Willi Syndrome. J Clin Endocrinol Metab. 2011; 96:E1314-9.

Smith EV, Hay P, Campbell LV and Trollor JN. A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment. Obesity Reviews 2011; 12:740-755.

Samocha-Bonet D, Wong O, Synnott, E-S, Piyaratna N, Douglas A, Gribble FM, Holst JJ, Chisholm DJ, Greenfield JR. Glutamine reduces postprandial glycaemia and augments the GLP-1 response in type 2 diabetes patients. J Nutrition 2011; 141: 1233-1238.

Martinelli CE, Keogh JM, Greenfield JR, Henning E, van der Klaauw AA, Blackwood A, O'Rahilly S, Roelfsema F, Camacho-Hubner C, Pijl H, Farooqi IS. Obesity due to Melanocortin 4 Receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed Growth Hormone secretion. J Clin Endocrinol Metab 2011; 96:E181-188E.

Greenfield JR. Invited review (Young Investigator Perspectives): Melanocortin signalling and the regulation of blood pressure in human obesity. Journal of Neuroendocrinology 2011; 23:186-193.

Campbell LV, Heitmann B. Gender bias in management of cardiovascular disease in women. Cardiology in General Practice.  2010; 14:30-31.

Viardot A, Sze L, Purtell L, Sainsbury A, Loughnan G, Smith E, Herzog H, Steinbeck K, Campbell LV. Prader-Willi Syndrome is associated with activation of the innate immune system independently of central adiposity and insulin resistance. J Clin Endocrinol Metab. 2010; 95:3392-9.

Tam CS, Viardot A, Clément K, Tordjman J, Tonks K, Greenfield JR, Campbell LV, Samocha-Bonet D, Heilbronn LK. Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans.  Diabetes. 2010; 59:2164-70.

Jenkins AB, Campbell LV. Insulin secretion and impaired glucose tolerance. Diabetologia. 2010; 53:2266-8.

Ta MT, Nguyen KT, Nguyen ND, Campbell LV, Nguyen TV. Identification of undiagnosed type 2 diabetes by systolic blood pressure and waist-to-hip ratio. Diabetologia 2010; 53:2139-46.

Samocha-Bonet D, Heilbronn LK, Lichtenberg D, Campbell LV. Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?  Trends Endocrinol Metab. 2010; 21:83-8.

Samocha-Bonet D, Campbell LV, Viardot A, Freund J, Tam CS, Greenfield JG, Heilbronn LK. A family history of type 2 diabetes increases risk factors associated with overfeeding. Diabetologia. 2010; 53:1700-8.


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