Clinical Obesity, Nutrition and Adipose Biology Lab

Selected Publications

Recent media releases:

TEDx talk "Starve to Survive"
www.youtube.com/watch?v=FoV3YCQSSzk

NSW Health "Make Healthy Normal Campaign"
www.makehealthynormal.nsw.gov.au

ABC Catalyst "Gut Reaction"
www.abc.net.au/catalyst/stories/4067184.htm

 

Recent Policy and Guidelines

2014     National Institute for Health and Clinical Excellence (UK) Feb 11, 2014

             An intervention framework for patients with psychosis on antipsychotic medication:

            “CG178 Psychosis and schizophrenia in adults: full guideline”

             http://guidance.nice.org.uk/CG178/InterventionFramework/pdf/English

 

2014    National Institute for Health and Clinical Excellence (UK) Feb 11, 2014

            HeAL Declaration (Healthy Active Lives for people with severe mental illness)

            Adopted as an implementation tool, CG178 Psychosis and schizophrenia in adults: full guideline.

 

2013   HeAL Declaration:     

           Tabled House of Lords, UK 11/6/13

           Endorsed by the Royal College of Psychiatrists (UK) 19/6/13

           Adopted by NSW Government by the Minister for Mental Health, 16/9/13

           Launched in Brussels, Europe as EuroHeAL, 3/10/13

           International launch, International Early Psychosis Association, Tokyo 17/11/14, with Lancet editorial.

 

2013   National Institute for Health and Clinical Excellence (UK), Clinical algorithm for metabolic health in mental illness into:

           “CG155 Psychosis and schizophrenia in children and young people: full guideline”
            http://guidance.nice.org.uk/CG155/InterventionFramework/pdf/English

 

2012   NSW Health “Metabolic Monitoring Form” (for people with severe mental illness)

           Published 27/7/12; document number IB2012_024; file number h12/46601

           www.health.nsw.gov.au/policies/ib/2012/IB2012_024.htm

 

2011   NSW Health “Don’t just screen, intervene” algorithm for metabolic monitoring in severe mental illness

           Adopted into the “Guidelines for Physical Health in Mental Health Consumers”   www.cadre.com.au/nsw_health/index.html

 

Recent publications:  Diabetes, obesity, adipose tissue and bariatric surgery/nutrition

Lim CP, Fisher OM, Falkenback D, Boyd D, Hayward CS, Keogh A, Samaras K, MacDonald P, Lord RV. Bariatric Surgery Provides a "Bridge to Transplant" for Morbidly Obese Patients with Advanced Heart Failure and May Obviate the Need for Transplantation. Obes Surg. 2016 Mar;26(3):486-93.

Peters TJ, Buckley MJ, Statham AL, Pidsley R, Samaras K, Lord RV, Clark SJ, Molloy PL. De novo identification of differentially methylated regions in the human genome. Epigenetics and Chromatin 2015; 8:6.

Samaras K, Morris MJ, Lord RV, Kavurma MM. The effect of bariatric surgery on serum TRAIL and osteoprotegerin levels in obesity complicated by glucose disorders. European e-Journal of Clinical Nutrition and Metabolism (e-SPEN) 2014.

Van Djik S, Molloy PL, Varinli H, Morrison JL, Muhlhauser BS, Buckley M, Clarke SJ, McMillen IC, Noakes M, Samaras K, Molloy P. Epigenetics and human obesity. Int J Obes 2014; 1-13.

Samaras K, Viardot A, Botelho NK, Jenkins A, Lord RV. Immune cell inflammation and the early improvements in glucose metabolism after gastric banding surgery. Diabetologia 2013; 56: 2564-72.

Samaras K, Lee PN, Jenkins A, Botelho NK, Bakopanos A, Lord RV, Hayward CS. Reduced arterial stiffness after weight loss in obese type 2 diabetes and impaired glucose tolerance: the role of immune cell activation and insulin resistance. Diabetes Vascular Dis Res 2013; 10:40-48.

Samaras K. Bariatric surgery in type 2 diabetes: for whom and when? (Invited Review). Minerva Endocrinologica 2013; 38:47-58.

Molloy P, Samaras K, Mulhuaser B, McMillen C. Chasing the 'ghost in our genes' to beat obesity. Med J Australia 2013 (on line 4/3/13, doi10.5694/mja13.10098).

Greenfield, JR, Samaras K, Campbell LV. Sugar-sweetened beverages, genetic risk and obesity (Letter) N Engl J Med 2013; 368:285.

Viardot A, Heilbronn LK, Samocha-Bonet D, Mackay F, Campbell LV, Samaras K. Obesity is associated with activated and insulin resistant immune cells. Diabetes Metabolism Research and Reviews 2012; 28:447-454.

Samaras K, Connolly S, Lord RV, MacDonald P, Hayward CS. Take heart: bariatric surgery in obese patients with severe heart failure. Two case reports. Heart, Lung, Circulation (ePub Jun 26, 2012).

Samaras K, Botelho NK, Chisholm DJ, Lord RV.  Subcutaneous and Visceral Adipose Tissue Gene Expression of Serum Adipokines That Predict Type 2 Diabetes. Obesity. 2010; 18:884-9. 

Samaras K, Botelho NK, Chisholm DJ, Lord RV. Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism and inflammatory adipokines in type 2 diabetes mellitus and in health. Obesity Surgery 2010; 20:108-113.

Viardot A, Lord RV, Samaras K. The effects of weight loss and gastric banding on the innate and adaptive immune system in type 2 diabetes and pre-diabetes. J Clin Endocrinol Metab 2010; 95:2845-50.

 

Recent publications: Diabetes and the brain

Samaras K, Crawford J, Lutgers HL, Campbell LV, Baune BT, Lux O, Brodaty H, Trollor JN, Sachdev PS. Metabolic, disease and mortality risk associated with impaired fasting glucose in the elderly.  J American Geriatric Society 2015; 63: 1435-42.

Samaras K, Lutgers HL, Kochan NA, Crawford J, Campbell LV, Wen W, Slavin MJ, Baune BT, Lipnicki DM, Brodaty H, Trollor JN, Sachdev PS. The impact of glucose disorders on cognition and brain volumes in the elderly: The Sydney Memory and Ageing Study.  Age 2014; 36: 977-93

Ahmed RM, Irish M, Kam J, van Keizerswaard J, Bartley L, Samaras K, Hodges JR, Piguet O. Quantifying the eating abnormalities in frontotemporal dementia. JAMA Neurol. 2014; 71: 1540-6.

Smith E, Bailey PE, Crawford J, Samaras K, Baune BT, Campbell LV, Kochan N, Manant J, Sturnieks DL, Brodaty H, Sachdev P, Trollor JN. Adiposity estimated using dual energy x-ray absorptiometry and body mass index and its association with cognition in elderly adults. J Am Geriatr Soc. 2014; 62: 2311-8.

Singer J, Trollor JN, Crawford J, O’Rourke M, Baune BT, Brodaty H, Samaras K, Kochan NA, Campbell L, Sachdev PS, Smith E. The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study. PLoS 2013; 8:e61855.

Fuchs T, Trollor JT, Crawford J, Brown D, Baune B, Samaras K, Campbell L, Breit SN, Brodaty H, Sachdev P, Smith E. Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline- the Sydney Memory and Ageing Study. Ageing Cell 2013: 12:882-9.

Samaras K, Sachdev P. Diabetes and the elderly brain: sweet memories? (Invited review). Therapetic advances in Endocrinology and Metabolism 2012; 3:189-195.

Samaras K, Crawford J, Baune BT, Campbell LV, Smith E, Lux O, Brodaty H, Trollor JN, Sachdev PS. The value of the Metabolic Syndrome concept in the elderly: Is it worth less than the sum of its parts? J American Geriatric Society 2012; 60:1734-41.

Baune BT, Smith E, Reppermund S, Air T, Samaras K, Lux O, Brodaty H, Sachdev P, Trollor JN Inflammatory markers predict depression, but not anxiety during aging: The Prospective Sydney Memory and Aging Study.  Psychoneuroendocrinology 2012; 37:1521-30.

Trollor JN, Smith E, Agars E, Kuan S, Baune BT, Kochan N, Campbell LV, Samaras K, Crawford J, Kochan N, Brodaty H, Sachdev P. The association of systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Aging Study.  Age 2011 (Epub Aug 19).

Trollor JN, Smith E, Baune BT, Kochan N, Campbell LV, Samaras K, Crawford J, Brodaty H, Sachdev P. Systemic inflammation is associated with mild cognitive impairment and its subtypes: the Sydney Memory and Aging Study. Dementia and Geriatric Cognitive Disorders 2010; 30:569-78. 

 

Recent publications: Diabetes, endocrinology and HIV

McMahon CN, Samaras K. Endocrine and metabolic emergencies- HIV and AIDS. (Invited textbook chapter) In: Endocrine and Metabolic Medical Emergencies. Editor-in-Chief: G. Matfin. Endocrine Press, Washington DC. 2014

McMahon CN, Blanchard E, Samaras K. Diabetes and dyslipidemia in treated HIV infection and approaches for cardiometabolic care. (Invited textbook chapter) In: Health of HIV Infected People. Editor: Dr R.W. Watson. Academic Press, Elsevier, Waltham, MA, USA.

Rider OJ, Asaad M, Ntusi N, Wainwright E, Clutton G, Hancock G, Pitcher A, Samaras K, Clarke K, Stefan N, Dorrell L, Holloway C. Human immunodeficiency virus is an independent predictor of aortic stiffness. J Cardiovasc Magnetic Resonance 2014; 16: 57.

Samaras K. The burden of diabetes and hyperlipidemia in treated HIV-infection and approaches for cardiometabolic care. (Invited Review) Current HIV/AIDS Reports 2012; 9:206-217.

Samaras K. Endocrine disease in HIV infection. Best Pract Res Clin Endocrin Metab. 2011; 25:vii-viii. 

Samaras K, Richardson R, Carr A. Postprandial lipid effects of low-dose ritonavir versus raltegravir in HIV-uninfected adults. AIDS 2010; 24:1727-31.

Samaras K, Wand H, Law M, Emery S, Cooper DA, Carr A.  Dietary intake in HIV-infected men with lipodystrophy: relationships with body composition, visceral fat, lipid, glucose and adipokine metabolism. Current HIV Research 2009; 7:454-61.

Samaras K. Prevalence and pathogenesis of diabetes mellitus in HIV infection treated with highly active antiretroviral therapy. JAIDS 2009; 50:499-505.

Samaras K, Gan SK, Peake P, Carr A, Campbell LV.  Proinflammatory Markers, Insulin Sensitivity, and Cardiometabolic Risk Factors in Treated HIV Infection. Obesity 2009; 17:53-9.

Samaras K. HIV, insulin resistance and cardiovascular disease. (Invited Review) Current Cardiology Reports 2009; 3:59-64.

Samaras K. How sweet it is? Susceptibility to diabetes mellitus in HIV-1 infection. (Invited review). HIV Therapy 2009; 3:613-24.

Samaras K. Endocrine Disorders. In: HIV management in Australia: A guideline for clinical care. (Invited Chapter) Editors: J Hoy and S Lewin, for the Australasian Society for HIV Medicine Inc and Australian Government, Department of Health and Ageing, 2009, 253-56.

Samaras K. Endocrine Disorders in HIV-infection. Fundamentals of Global HIV Medicine. American Academy for HIV Medicine Eds: Temesgen Z, Gilliam B, Amoroso A, Goosby E. IHL Press, MA, USA, 2009. Chapter 24, pp 211-281; ISBN: 978-0-9754188-2-6

Calmy A, Norris R, Fux C, Vallier N, Samaras K, Hesse K, Hirschel B, Cooper DA, Carr A. Fracture risk associated with low bone mineral density in HIV-infected individuals: a cross-sectional study. J Infect Dis 2009; 200:1746-54

Samaras K. Metabolic consequences and therapeutic options in highly active antiretroviral therapy in human immunodeficiency virus-1 (HIV) infection. (Invited review). J Antimicrobial Chemotherapy 2008; 61:238-245.

Grunfeld C, Kotler DP, Arnett DK, Falutz JM, Haffner SM, Hruz P, Masur H, Meigs JB, Mulligan K, Reiss P, Samaras K; Working Group 1. Contribution of metabolic and anthropometric abnormalities to cardiovascular disease risk factors. Circulation. 2008; 118:e20-8.

Calmy A, Carey D, Mallon PW, Wand H, Law M, Cooper DA, Carr A; INITIO Trial International Co-ordinating Committee; HAMA study coordination team. Early changes in adipokine levels and baseline limb fat may predict HIV lipoatrophy over 2 years following initiation of antiretroviral therapy. HIV Med. 2008; 9:101-10.

Bradbury R, Samaras K. Anti-retroviral therapy and the human immunodeficiency virus- improved survival but at what cost? Diabetes Obesity and Metabolism 2008; 10:441-50.

Mallon PWG, Sedwell R, Rogers G, Nolan D, Unemori P, Hoy J, Samaras K, Kelleher A, Emery S, Cooper D, Carr A for the Rosey investigators. The effect of rosiglitazone on PPAR-gamma gene expression in human adipose tissue is limited by antiretroviral drug-induced mitochondrial dysfunction. J Inf Dis 2008; 198:1794-803.

Samaras K, Wand H, Law M, Emery S, Cooper DA, Carr A. Metabolic Syndrome in HIV-infected patients using IDF and ATPIII criteria: prevalence, discordance and clinical utility. Diabetes Care 2007, 30:113-9.

Samaras K, Chisholm DJ. Diabetes, insulin resistance and glucose metabolism in HIV infection and its treatment. In: The Epidemiology of Diabetes Mellitus: An International Perspective. Editors: Ekoe J-M, Zimmet P, Williams R, Rewers M. John Wiley and Sons, 2008, pp 665-675.

Wand H, Calmy A, Carey DL, Samaras K, Carr A, Law MG, Cooper DA, Emery S. Metabolic Syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV-infection. AIDS 2007; 21:2445-53.


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