Eating Disorders Lab

Selected Publications

Chi Kin Ip, Lei Zhang, Aitak Farzi, Ireni Clarke, Felicia Reed, Yan-Chuan Shi, Ronaldo Enriquez, Yue Qi, Chris Dayas, Bret Graham, Denovan Begg, Jens C Brüning, Nicola J Lee, Diana Hernandez-Sanchez, Gopana Gopalasingam,Julia Koller, Ramon Tasan, Günther Sperk & Herbert Herzog. (2019) Amygdala NPY circuits promote the development of accelerated obesity under chronic stress conditions. Cell Metabolism, in press.

Seiki Fujiwara, Dennis Lex, Hiroyuki Takao, Masahiro Gando, Ryujiro Hara, Herbert Herzog, Akihiko Yoshimura, Hitoshi Okamura, Josef M. Penninger, Arthur S. Slutsky, Stefan Uhlig, Keiji Kuba, & Yumiko Imai (2019) Pulmonary phagocyt-derived NPY and Y1 receptor axis controls the pathology of severe influenza virus infection. Nature Microbiology,  Nov 19. doi: 10.1038/s41564-018-0289-1

Zhang, L., Ip, CK., Lee, I-Chieh J., Reed, F., Qi, Y., Karl, T., Low, JK., Baldock, P.A. & Herzog, H. (2018) Diet-induced adaptive thermogenesis requires Neuropeptide FF receptor-2 signalling. Nat Commmun.  Nov 9;9(1):4722. doi: 10.1038/s41467-018-06462-0

Farzi, A., Lau, Ip, CK., Qi, Y., Shi, YC., Zhang, L., Tasan, R., Sperk, & Herzog, H. (2018) Opposing effects of arcuate nucleus and lateral hypothalamic CART neurons on energy expenditure. elife, Aug 21;7. pii: e36494.

Lee, N.J., Zhang, L., Clarke, I.M., Enriquez, R.F., Ali, N., Brzozowska, M., Lee, I.C., Laybutt, R.D., Rogers, M., Center, J.R., Baldock, P.A. & Herzog, H. (2018) Osteoglycin, a novel coordinator of bone and glucose homeostasis. Mol Metabolism May 8. pii: S2212-8778(18)30295-3. – Highlighted in Nature Review Endocrinology

 Lau, J., Farzi, A., Qi, Y.,  Heilbronn, R., Mietzsch, M., Shi, Y.C. &  Herzog, H. (2017) CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis. Molecular Metabolism , Jan;7:102-118.

Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H. (2017) Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8(1):490.

Wang, Q.P.,  Simpson, S.J., Herzog, H. & Neely, G.G. (2017) Chronic Sucralose or L-Glucose Ingestion does not Suppress Food Intake. Cell Metabolism.   1;26(2):279-280.

Loh, K., Zhang,  L., Brandon, A.,  Wang, Q.,  Begg, D.,  Qi,  Y.,  Fu, M.,  Kulkarni, R.,  Teo, J.,  Baldock, P.,  Bruning, JC.,  Cooney, G.,  Neely, G. &  Herzog, H. (2017) Insulin Controls Food Intake and Energy Balance via NPY Neurons. Molecular Metabolism. 12;6(6):574-584

Wang, Q.P.,  Lin, Y.Q., Zhang, L., Wilson, Y.A.,  Oyston,  L.J.,  Cotterell, J., Qi, Y.,  Khuong, T.M., Bakhshi, N., Planchenault, Y.,  Browman, D.T., Lau, M.T., Cole, T.A.,  Wong, N.,  Simpson, S.J., Cole, A.R.,  Penninger, J.M., Herzog, H*. & Neely, G.G*. (2016) Artificial sweeteners promote food intake through a neuronal fasting response. Cell Metabolism. 12;24(1):75-90. *co-correspondent

Lee, N.J., Nguyen, A.D., Enriquez, R.F., Luzuriaga, J., Bensellam, M., Rogers, M., Laybutt, D.R., Baldock, P.A., Herzog, H. (2015) NPY signalling in osteoblasts controls glucose homeostasis. Molecular Metabolism. 4(3), 164-174.

Shi, Y.C., Loh, K., Bensellam, M., Zhai, L., Lee, K., Lau, K., Cantley, K.J., Laybutt, D.R., & Herzog, H. (2015) Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in mice. Endocrinology, 156(9):3122-36. (Cover)

Yulyaningsih, E.,* Loh, K.,* Lin, S.,* Lau, J.. Zhang, L., Shi, Y., Berning, B.A., Enriquez, R., Driessler, F., Macia, L., Khor, E.C., Qi, Y., Baldock, P., Sainsbury, A.,* Herzog, H.* (2014) Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism, Jan 7;19(1):58-72. * equal first/last

Baldock, P.A., Lin, S., Zhang, L., Karl, T., Shi, Y-C., Driessler, F., Zengin, A., Hörmer, B., Lee, N., Wong, I.P.L., Lin, E-J.D., Enriquez, R.F., Stehrer, B., During, M., Yulyaningsih, E., Zolotukhin, S., , Ruohonen, S.T., Savontaus, E., Sainsbury, A., Herzog, H. (2013) Neuropeptide Y attenuates stress-induced bone loss through suppression of noradrenaline circuits. J Bone Miner Res. Oct;29(10):2238-49

Wong, I.P., Nguyen, A.D., Khor, E.C., Enriquez, R.F., Eisman, J.A., Sainsbury, A., Herzog, H*., Baldock, P.A*. (2013) Neuropeptide Y is a critical modulator of leptin’s regulation of cortical bone. J Bone Miner Res. 28(4), 886-898. *equal last authors

Shi, Y-C., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X-F., Enriquez, R., Castillo, L., Baldock, P., Zhang, L. Sainsbury, A., Herzog, H.*, Lin, S*. (2013) Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metabolism. 17(2), 236-48. *equal last authors

Nguyen, A.D., Mitchell, N.F., Lin, S., Macia, L., Yulyaningsih, E., Baldock, P.A., Enriquez, R.F., Zhang, L., Shi, Y-C., Zolotukhin, S., Sainsbury, A.*, Herzog, H.* (2012) Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice. PLoS One. 7(6), e40191. Jul 7. equal last authors

Macia, L., Yulyaningsigh, E., Pangon, L., Nguyen, A.D., Lin, S., Shi, YC., Zhang, L., Bijker, M., Grey, S., Mackay, F., Sainsbury, A.*, Herzog, H.* (2012) Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity. Diabetes. 61(12), 3228-3238 *equal last authors

Shi, YC., Lin, S.,  Wong, I., PL., Baldock, P.A., Aljanova, A., Enriquez, R.F., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Macia, L., Yulyaningsih, E., Nguyen, A.D., Riepler, S., Sainsbury, A.* & Herzog, H.* (2010) NPY neuron-specific Y2 receptors regulate adipose but not skeletal tissue homeostasis in mice. PLoS One. 5(6), e11361. *equal last authors

Lee, N.J., Doyle, K., Sainsbury, A., Enriquez, R.F., Hort, Y.J., Riepler, S.J., Baldock, P.A.. Herzog, H. (2010) Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity.  J. Bone Miner. Res. 25(8), 1736-1747.

Cox, H.M., Iain, R., Tough, R.I., Woolston, A.M., Zhang, L., Nguyen, A.D., Sainsbury, A. Herzog H (2010) Peptide YY is critical for Gpr119-induced activation of gastrointestinal mucosal responses.  Cell Metabolism. 11(6), 532-542.

Allison, S.J., Baldock, P.A., Enriquez, R.F., Lin E.J., During, M.J., Gardiner, E.M., Eisman, J.A., Sainsbury, A.* & Herzog H.* (2009) Critical interplay between neuropeptide Y and sex steriod pathways in bone and adipose tissue homeostasis. J. Bone Miner. Res. 24(2): 294-304. *equal last authors

Lin, S., Shi, YC., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A.D., Lin, E.J., During, M.J., Sainsbury, A.* & Herzog, H.* (2009) Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLoS One. 4(12):e8488. *equal last authors

Baldock, P.A., Lee, N.J., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E.J., Zhang, L., Enriquez, R.F., Wong, I., PL., McDonald, M.M., During, M., Pierroz, D.D., Slack, K., Shi, YC., Yulyaningsih, E., Aljanova, A., Little, D.G., Ferrari, S.L., Sainsbury, A., Eisman, J.A., Herzog H (2009) Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to bodyweight. PLoS One. 4(12):e8415.

Lundberg, P., Allison, S.J., Lee, N.J., Baldock, P.A., Brouard, N., Rost, S., Enriquez, R.F., Sainsbury, A., Lamghari, M., Simmons, P., Eisman, J.A., Gardiner, E.M., Herzog, H. (2007) Greater bone formation of Y2 knockout mice is caused by increased osteoprogenitor number and downregulation of Y1 receptors on these cells. J Biol. Chem. 282(26), 19082-91.

Johnen, H., Lin, S., Kuffner, T., Brown, D.A., Tsai, V.W.W., Bauskin, A.R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., Hunter, M., Fairlie, W.D., Lee, N.J., Enriquez, R.F., Baldock, P.A., Corey, E., Apple, F.S., Murakami, M.M., Lin, E.J., Wang, C., During, M.J., Sainsbury, A., Breit, S.N.* & Herzog, H.* (2007) Tumour-induced anorexia and weight loss are mediated by the TGF-b superfamily cytokine MIC-1. Nat. Med. 13(11), 1333-1340. *equal last authors

Kuo, L.E., Kitlinska, J.B., Tilan, J.U., Li, L., Baker, S.B., Johnson, M.D., Lee, E.W., Burnett, M.S., Fricke, S.T., Kvetnansky, R.K., Herzog, H., Zukowska, Z. (2007) Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat. Med. 13(7), 803-11.

Baldock, P.A., Allison, S.J., Lundberg, P., Lee, N.J., Slack, K., Lin E.J., Enriquez, R.F., McDonald, M.M., Zhang, L., During, M.J., Little, D.G., Eisman, J.A., Gardiner, E.M., Yulyaningsih, E., Lin, S., Sainsbury, A.* & Herzog, H.* (2007) Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis. J Biol. Chem. 282(26), 19092-19102. *equal last authors

Baldock, P.A., Allison, S., McDonald, M.M., Sainsbury, A., Enriquez, R.F., Little, D.G., Eisman, J.A., Gardiner, E.M., Herzog, H. (2006) Hypothalamic regulation of cortical bone mass: Opposing activity of Y2 receptor and leptin pathways. J. Bone Miner. Res. 21(10), 1600-7.

Allison, S., Baldock, P.A., Sainsbury, A., Enriquez, R.F., Lee, N.J., Lin, E.J.D., During, M.J., Gardiner, E.M.* & Herzog, H.* (2006) Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice. J. Biol. Chem. 281(33), 23436-44. *equal last authors

Sainsbury, A., Bergen, H.T., Boey, D., Bamming, D., Cooney, G., Lin, S., Couzens, M., Stroth, N., Lee, N.J., Herzog, H. (2006) Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice. Diabetes. 55(1), 19-26.

Boey, D., Lin, S., Karl, T., Baldock, P.A., Lee, N.J., Enriquez, R.F., Couzens, M., Sainsbury, A., Herzog, H. (2006) Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity. Diabetologia. 49(6), 1360-70.

Batterham, R.L., Chivers, J.E., Kapoor, S., Heffron, H., Le Roux, C.W., Thomas, L., Bell, J.D., Herzog, H., Withers, D.J. (2006) Critical role for peptide YY in protein-mediated satiation and body weight regulation. Cell Metabolism. 4(3), 223-233.

Wheway, J., Mackay, C.R., Newton, R., Sainsbury-Salis, A., Boey, D., Mackay, F.* & Herzog, H.* (2005) A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J. Exp. Med. 202(11), 1527-38. *equal last authors

Karl, T., Schwarzer, C., Lin, S., Sainsbury, A., Boey, D. Couzens, M., von Hörsten, S., Herzog, H. (2004) Y1 receptors regulate aggressive behavior by modulating sertonin pathways. Proc. Natl. Acad. Sci. USA (Track II). 101, 12742-12747.

Sainsbury, A., Schwarzer, C., Couzens, M., Herzog, H. (2002) Y2 receptor deletion attenuates the diabetic syndrome of genetically obese ob/ob mice. Diabetes. 51(12), 3420-3427.

Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Fürtinger, S., Jenkins, A., Cox, H.M., Sperk, G., Hökfelt, T., Herzog, H. (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. USA (Track II). 99, 8938-8943.

Baldock, P.A., Sainsbury, A., Couzens, M., Enriquez, R.F., Gardiner, E.M., Herzog, H. (2002) Hypothalamic Y2 receptors regulate bone formation. J. Clin. Invest. 109, 915-921.

Batterham, R., Cowley, M., Small, C., Herzog, H., Cohen, M., Dakin, C., Wren, A., Brynes, A., Low, M., Ghatei, M., Cone, R., Bloom, S. (2002) Gut hormone, PYY3-36 physiologically inhibits food intake. Nature.  418, 650-654.

Parker, R.M.C., Herzog, H. (1999) Regional distribution of Y-receptor subtype mRNAs in the rat brain. Eur. J. Neurosci. 11, 1431-1448.

Darby, K., Eyre, H.J., Lapsys, N., Copeland, N.G., Gilbert, D.J., Couzens, M., Antonova, O., Sutherland, G.R., Jenkins, N.A., Herzog, H. (1997) Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14. Genomics. 46, 513-515.

Sainsbury, A., Schwarzer, C. Couzens, M., Jenkins, A., Oakes, S.R., Ormandy, C.J., Herzog, H. (2002) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev. 16, 1077-1088.

Hort, Y.J., Baker, E., Shine, J., Herzog, H. (1995) Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1. Genomics. 26, 77-83.

Herzog, H., Hort, Y.J., Schneider, R., Shine, J. (1995) Seminalplasmin: Recent evolution of a new member of the neuropeptide Y gene family. Proc. Natl. Acad. Sci. USA. 92, 594-598.

Ball, H., Shine, J., Herzog, H. (1995) Multiple promoters regulate tissue-specific expression of the human NPY-Y1 receptor gene. J. Biol. Chem. 270, 27272-27276.

Herzog, H., Hort, Y.J., Shine, J., Selbie, L. (1992) Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl. Acad. Sci. USA. 89, 5794-5798.


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