Skeletal Metabolism Lab

Selected Publications

Horsnell H, Baldock PA. Osteoblastic Actions of the Neuropeptide Y System to Regulate Bone and Energy Homeostasis. Curr Osteoporos Rep. 2016 Feb;14(1):26-31.

Khor EC, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni RN, Enriquez RF, Purtell L, Lee NJ, Wee NK, Croucher PI, Campbell L, Herzog H, Baldock PA. Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PLoS One. 2016 Jan 29;11(1):e0148155.

Khor EC, Yulyaningsih E, Driessler F, Kovaĉić N, Wee NK, Kulkarni RN, Lee NJ, Enriquez RF, Xu J, Zhang L, Herzog H, Baldock PA. The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay. Bone. 2016 Mar;84:139-47.

Wee NK, Kulkarni RN, Horsnell H, Baldock PA. The brain in bone and fuel metabolism. Bone. 2016 Jan;82:56-63.

Houweling P, Kulkarni RN, Baldock PA. Neuronal control of bone and muscle. Bone. 2015 Nov;80:95-100.

Wee NK, Baldock PA. The hunger games of skeletal metabolism. Bonekey Rep. 2014 Nov 12;3:588.

Khor EC, Wee NK, Baldock PA. Influence of hormonal appetite and energy regulators on bone. Curr Osteoporos Rep. 2013 Sep;11(3):194-202.

Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF, Enriquez RF, Castillo L, Baldock PA, Zhang L, Sainsbury A, Herzog H, Lin S. Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN. Cell Metab. 2013; 5:236-48.  

Sousa DM, McDonald MM, Mikulec K, Peacock L, Herzog H, Lamghari M, Little DG, Baldock PA. Neuropeptide Y modulates fracture healing through Y1 receptor signaling. J Orthop Res. 2013; 31:1570-8

McDonald MM, Morse A, Mikulec K, Peacock L, Baldock PA, Kostenuik P, Little DG. MMP driven endochondral fracture union proceeds independently of osteoclast activity. J Bone Miner Res. 2013; 28:1550-60.

Brzozowska MM, Sainsbury A, Eisman JA, Baldock PA, Center JR. Bariatric surgery, bone loss and possible mechanisms. Obes Rev. 2012; 14:52-67

Wong IP, Nguyen AD, Khor EC, Enriquez RF, Eisman JA, Sainsbury A, Herzog H, Baldock PA. Neuropeptide Y is a critical modulator of leptin's regulation of cortical bone. J Bone Miner Res. 2012; 28:886-98.

Baldock PA, Driessler F, Lin S, Wong IP, Shi Y, Yulyaningsih E, Castillo L, Janmaat S, Enriquez RF, Zengin A, Kieffer BL, Schwarzer C, Eisman JA, Sainsbury A, Herzog H. The endogenous opioid dynorphin is required for normal bone homeostasis in mice. Neuropeptides. 2012; 46(6):383-94

Wong IPL, Driessler F, Shi Y-C, Hörmer B, Nguyen AD, Enriquez RF, Eisman JA, Sainsbury A, Herbert Herzog H,  Baldock PA.  Peptide YY regulates bone remodeling in mice: A link between gut and skeletal biology. PLoS One 2012; 7:e40038.

Pierroz DD, Bonnet N, Bianchi EN, Bouxsein ML, Baldock PA, Rizzoli R, Ferrari SL.  Deletion of β-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation. J Bone Miner Res. 2012; 27(6):1252-62.

McDonald MM, Morse A, Mikulec K, Peacock L, Yu N, Baldock PA, Birke O, Liu M, Ke HZ, Little DG.  Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats. J Orthop Res. 2012; 30:1541-8.

Zengin A, Nguyen AD, Wong IP, Zhang L, Enriquez RF, Eisman JA, Herzog H, Baldock PA, Sainsbury A. Neuropeptide Y mediates the short-term hypometabolic effect of estrogen deficiency in mice. Int J Obes (Lond). 2012; 37(3):390-8.

Sousa DM, Baldock PA, Enriquez RF, Zhang L, Sainsbury A, Lamghari M, Herzog H.  Neuropeptide Y Y1 receptor antagonism increases bone mass in mice. Bone 2012; 51:8-16.

Lee NJ, Nguyen AD, Enriquez RF, Doyle KL, Sainsbury A, Herzog H,  Baldock PA. Osteoblast specific Y1 receptor deletion enhances bone mass. Bone. 2011; 48:461-7.

Lee NJ, Allison S, Enriquez RF, Sainsbury A, Herzog H, Baldock PA. Y2 and Y4 receptor signalling attenuates the skeletal response of central NPY. J Molec Neurosci  2010; 43:123-31. 

Pierroz DD, Bonnet N, Baldock PA, Ominsky MS, Stolina M, Kostenuik PJ, Ferrari SL. Are osteoclasts needed for the bone anabolic response to PTH? A study of intermittent PTH with Denosumab or alendronate in knock-in mice expressing humanized RANKL. J Biol Chem. 2010; 285:28164-73.

Shi YC, Lin S, Wong IP, Baldock PA, Aljanova A, Castillo L, Mitchell NF, Ye JM, Macia L, Yulyaningsih E, Nguyen AD, Herzog H, Sainsbury A.  NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. PLoS One. 2010; 29;5:e11361

Lee NJ, Doyle KL, Sainsbury A, Enriquez RF, Hort YJ, Riepler SJ, Baldock PA, Herzog H. Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity. J Bone Miner Res. 2010; 25:1736-47.  

Baldock PA, Lee NJ, Driessler F, Lin S, Allison S, Stehrer B, Lin EJ, Zhang L, Enriquez RF, Wong IP, McDonald MM, During M, Pierroz DD, Slack K, Shi YC, Yulyaningsih E, Aljanova A, Little DG, Ferrari SL, Sainsbury A, Eisman JA, Herzog H. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to bodyweight. PLoS One 2009; 4 :12 e8415.

Igwe JC, Jiang X, Paic F Ma L, Adams DJ, Baldock  PA, Pilbeam C, Kalajzic I. Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity. J Cell Biochem 2009; 108:621-630.

Baldock PA, Allison SJ, Enriquez RF, Lin, EJ, During M, Gardiner, EM, Eisman JA, Sainsbury A, Herzog H. Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis. J Bone Miner Res 2008; 24:294-304.

Lee NJ, Enriquez RF, Boey D, Lin S, Slack K, Baldock PA, Herzog H, Sainsbury A. Synergistic attenuation of obesity by Y2 and Y4 receptor double knockout in ob/ob mice. Nutrition. 2008; 24:892-9.

Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, Bauskin AR, Wu L, Pankhurst G, Jiang L, Junankar S, Hunter M, Fairlie WD, Lee NJ, Enriquez R, Baldock PA, Corey E, Apple FS, Murakami MM, Lin EJ, Wang C, During MJ, Sainsbury A, Herzog H, Breit SN. Tumour-induced anorexia and weight loss is mediated by the TGF-b superfamily cytokine MIC-1. Nat Med 2007; 13:1333-1340.

Baldock PA, Allison SJ, Lundberg P, Lee NJ, Slack K, Lin EJD, Enriquez RF, McDonald MM, Zhang L, During MJ, Little DG, Eisman JA, Gardiner EM, Yulyaningsih E, Lin S, Sainsbury A, Herzog H. Novel role of Y1 Receptors in the Coordinated Regulation of Bone and Energy Homeostasis. J Biol Chem 2007; 282:19092-19102.

Lundberg P, Allison SJ, Lee N, Baldock PA, Brouard N, Rost S, Enriquez R, Sainsbury A, Lamghari M, Simmons P, Eisman JA, Gardiner EM, Herzog H. Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1-receptor expression. J Biol Chem 2007; 282:19082-19091.

Allison S, Baldock PA, Sainsbury A, Enriquez RF, Lee NJ, Lin EJD, Klugman M, During M, Eisman JA, Li M, Pan LC, Herzog H, Gardiner EM. Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice.  J Biol Chem. 2006; 281:23436-23444.

Baldock PA, Allison S, Mc Donald MM, Sainsbury A, Enriquez RF, Little DG, Eisman JA, Gardiner EM, Herzog H. Hypothalamic Regulation of Cortical Bone Mass: Opposing Activity of Y2 Receptor and Leptin Pathways.  J Bone Miner Res. 2006; 21:1600-1607.

Baldock PA, Sainsbury A, Allison S, Lin D, Couzens M, Boey D, Enriquez, RF, Lin S, During M, Herzog H, Gardiner, EM.  Hypothalamic control of bone formation: Distinct actions of leptin and Y2 receptor pathways. J Bone Miner Res. 2005; 20:1851-1857.

Baldock PA, Sainsbury A, Schwarzer C, Ueno N, Enriquez RF, Couzens M, Inui A, Herzog H, Gardiner EM. Synergistic Reduction in Adiposity and Increase in Bone Mass in Y2 / Y4 Receptor Double Knockout Mice. Mol Cell Biol, 2003; 23: 5225-5233

Little DG, Peat R, McEvoy A, Williams P, Smith E, Baldock PA. Zolendroic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young wistar rats. J Bone Miner Res 2003; 18:2016 –2022.

Baldock PA, Sainsbury A, Couzens M, Enriquez RF, Thomas GP, Gardiner EM, Herzog H. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 2002; 109:915-921.

Gardiner EM, Baldock PA, Thomas GP, Sims NA, Henderson NK, Hollis B, White CP, Sunn KL, Morrison NA, Walsh WR, Eisman J. Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage. FASEB J 2000; 14:1908-1916.


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