Prof Jenny Gunton

Visiting Scientist

Laboratory Head

Conjoint/Adjunct Role(s)

President, Australian Diabetes Society

Associate Professor Jenny Gunton is head of the Diabetes and Transcription Factors Group at the Garvan Institute in Sydney, and is an Endocrinologist with a 20% Staff Specialist appointment at Westmead Hospital.

The research focuses of her laboratory are beta-cell function and liver diseases. She was elected to Council of the Australian Diabetes Society in 2006 and is the current President. She is on the Pharmaceutical Benefits Advisory Committee.

Research Interests

Beta cells
Transcription factors
Type 2 diabetes
Type 1 diabetes
Islet transplantation
Gene expression


CJ Martin Fellow, Garvan Institute of Medical Research, Sydney - Australia
Post-doctoral Fellowship, Joslin Diabetes Center & Harvard Medical School - USA
PhD, University of Sydney - Australia
FRACP, Fellow of the Royal Australasian College of Physicians
MBBS, Bachelor of Medicine, Bachelor of Surgery University of Queensland - Australia

Selected Publications

Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE. The Roles of Vitamin D in Skeletal Muscle: Form, Function and Metabolism. Endocrine Reviews. Feb 2013; 34:33-83.

Ding N, Yu RT, Subramanium N, Leblanc M, Wilson C, Rao R, He M, Coulter S, Scott C, Sherman M, Lau SL, Atkins AR, Barish GD, Gunton, JE, Liddle C, Downes M, Evans RM. A Master Cistromic Circuit Governing Hepatic Fibrogenesis. CELL, 2013; 153(3): 601-613.

RA Stokes, K Cheng, NA Deters,  SM Lau, WJ Hawthorne, PJ O’Connell, J Stolp, ST Grey, T Loudovaris, TW Kay, H Thomas, F J Gonzalez, JE Gunton.  Hypoxia-inducible factor 1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell Transplantation. 2013. Volume 22, Number 2, pp. 253-266(14).

P J O’Connell, DJ Holmes-Walker, D Goodman, W J Hawthorne, T Loudovaris, J E Gunton, H E Thomas, S T Grey, C J Drogemuller, G M Ward, A J Jenkins, D J Torpy, P T Coates, T W Kay Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. American J. Transplantation, 2013 in press.

Lau SM, Cha KM, Karunatillake, A, Stokes RA, Cheng K, McLean M, Cheung NW, Gonzalez FJ, Gunton JE. Beta-cell ARNT is required for normal glucose tolerance in pregnancy. PLoS One 2013; 8 (10): e77419.

Girgis CM, Lau SL, Clifton-Bligh RJ, GUNTON JE. Direct Effects of VDR Ablation on Bone Mass. Endocrinology. 2013. In Press.

Girgis CM, Clifton-Bligh RJ, Turner N, Lau SL, Gunton JE. Vitamin D and Skeletal Muscle Function. Clinical Endocrinology. 2013. In Press.

J. E. Gunton, M. Sisavanh, R.A. Stokes, J. Satin, L. S. Satin, M. Zhang, S. M. Liu, W.Cai, K. Cheng, G. J. Cooney, D. R.Laybutt, T. So, J. C.Molero, S. T. Grey, D. A. Andres, M. S. Rolph, C. R. Mackay. Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. PLoS One. 2012. 7(6): e39462. Cites: 2.

S.M. Lau, S. Lin, R.A. Stokes, K. Cheng, P.A. Baldock, R.F. Enriquez, M. McLean, N.W. Cheung, A. Sainsbury, F.J. Gonzalez, H. Herzog, J.E. Gunton. Synergistic effects of genetic beta cell dysfunction and maternal glucose intolerance on offspring metabolic phenotype in mice. Diabetologia 2011. 54 (4); 910-921. Cites: 4

Lau SL, Gunton JE (* corresponding author), Athayde NP, Byth K, Cheung NW. Serum 25-hydroxyvitamin D and glycated hemoglobin levels in women with gestational diabetes mellitus. Med J Aus. 2011 April 194; 334-337. Cover, editorial.

Kim Cheng, Kenneth Ho, Rebecca Stokes, Christopher Scott, SueMei Lau, Wayne Hawthorne, Philip O'Connell, Thomas Loudovaris, Thomas Kay, Rohit Kulkarni, Terumasa Okada, Xiaohui Wang, SunHee Yim, Yatrik Shah, Shane Grey, Andrew Biankin, James Kench, D. Ross Laybutt, Frank Gonzalez, C. Ronald Kahn, Jenny E GUNTON. Hypoxia-Inducible Factor-1α Regulates β-Cell Function in Mouse and Human Islets. Journal of Clinical Investigation 2010; 120 (6): 2171-2183.

XL. Wang, R Suzuki, K Lee, T Tran, J.E. Gunton, AK Saha, M-E Patti, A Goldfine, NB. Ruderman, FJ. Gonzalez, and CR Kahn. Acute Ablation of ARNT/ HIF-1b in Liver Results in Elevated Gluconeogenesis, Dyslipiemia and Hypoketonemia. Cell Metabolism 2009; 9: 428-439.

GUNTON JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi R, O’Connell PJ, Gonzalez FJ, Kahn CR. Loss Of ARNT/HIF1β Mediates Altered Gene Expression And Pancreatic Islet Dysfunction In Human Type 2 Diabetes. CELL 2005; 122: 337-349.

Gunton JE, Cheung NW, Hitchman R, Hams G, Sullivan C, Foster-Powell K, McElduff A. Chromium supplementation does not improve glucose tolerance, insulin sensitivity or lipid profile: a randomized, placebo-controlled, double blind trial of supplementation in subjects with impaired glucose tolerance. Diabetes Care 2005; 28: 712-713.

Gunton JE, Delhanty PJD, Takahashi S-I, Baxter, R. Metformin rapidly increases insulin receptor activation in human liver, and signals preferentially through insulin-receptor substrate-2. Journal of Clinical Endocrinology and Metabolism, 2003; 88: 1323-1332.

Prof Jenny Gunton