Immunology and Immunodeficiency Lab

Selected Publications

V Béziat, J Li, JX Lin, CS Ma, P Li, A Bousfiha, I Pellier, S Zoghi, S Baris, S Keles, PE Gray, N Du, Y Wang, Y Zerbib, R Lévy, T Leclercq, F About, AI Lim, G Rao, K Payne, SJ Pelham, DT Avery, EK Deenick, B Pillay, J Chou, R Guery, A Belkadi, A Guérin, M Migaud, V Rattina, F Ailal, I Benhsaien, M Bouaziz, H Tanwir, D Chaussabel, N Marr, J El Benna, B Grimbacher, O Wargon, J Bustamante, B Boisson, I Müller-Fleckenstein, B Fleckenstein, MO Chandesris, M Titeux, S Fraitag, MA Alyanakian, M Leruez-Ville, C Picard, I Meyts, JP Di Santo, A Hovnanian, A Somer, A Ozen, N Rezaei, T Chatila, L Abel, WJ Leonard°, SG Tangye°, A Puel*, JL Casanova* (°,* equal contribution). A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcriptionand activity. Sci Immunol 2018; 3(24)

Burnett, D. L.; Langley, D. B.; Schofield, P.; Hermes, J. R.; Chan, T. D.; Jackson, J.; Bourne, K.; Reed, J. H.; Patterson, K.; Porebski, B. T.; Brink, R.; Christ, D.; Goodnow, C. C. Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination. Science  2018 Apr 13;360(6385):223-226. doi: 10.1126/science.aao385Tangye SG. Is it dead or alive? TLR8 can tell. Nature Immunology 2018; 19:324-326. DOI: 10.1038

Bousfiha A, Jeddane L, Picard C, Ailal F, Bobby Gaspar H, Al-Herz W, Chatila T, Crow YJ, Cunningham-Rundles C, Etzioni A, Franco JL, Holland SM, Klein C, Morio T, Ochs HD, Oksenhendler E, Puck J, Tang MLK, Tangye SG, Torgerson TR, Casanova JL, Sullivan KE. The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. Journal of Clinical Immunology 2018; 38:129-143. DOI: 10.1007

Deenick EK, Morey A, Danta M, Emmett L, Fay K, Gracie G, Ma CS, Macintosh R, Smith Sabc, Sasson SC, Sewell WA, Cowley M, Tangye SG, Kelleher AD, Circa, Phan TG. Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency. Journal of Clinical Immunology 2018; 38:159-162. DOI: 10.1007

Jimenez-Reinoso A, Marin AV, Subias M, Lopez-Lera A, Roman-Ortiz E, Payne K, Ma CS, Arbore G, Kolev M, Freeley SJ, Kemper C, Tangye SG, Fernandez-Malave E, Rodriguez de Cordoba S, Lopez-Trascasa M, Regueiro JR. Human plasma C3 is essential for the development of memory B, but not T, lymphocytes. Journal of Clinical Immunology 2018; 141:1153-1154. DOI: 10.1016/j.jaci.2017.09.037 

Picard C, Bobby Gaspar H, Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Crow YJ, Cunningham-Rundles C, Etzioni A, Franco JL, Holland SM, Klein C, Morio T, Ochs HD, Oksenhendler E, Puck J, Tang MLK, Tangye SG, Torgerson TR, Sullivan KE. International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity. Journal of Clinical Immunology 2018; 38:96-128. DOI: 10.1007464-9 

Koutsakos M, Wheatley AK, Loh L, Clemens EB, Sant S, Nüssing S, Fox A, Chung AW, Laurie KL, Hurt AC, Rockman S, Lappas M, Loudovaris T, Mannering SI, Westall GP, Elliot M, Tangye SG, Wakim LM, Kent SJ, Nguyen THO, Kedzierska K. Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity. Sci Transl Med 10:428  

Infantino S, Light  A, O'Donnell K,  Bryant V, Avery DT, Elliott M,  Tangye SG,  Belz G, Mackay F,  Richard S, Tarlinton D. Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.Nat Commun. (Dec 2017)  8:891 

Conor J. Kearney, Stephin J. Vervoort, Kelly M. Ramsbottom, Andrew J. Freeman, Jessica Michie, Jane Peake, Jean-Laurent Casanova, Capucine Picard, Stuart G. Tangye, Cindy S. Ma, Ricky W. Johnstone, Katrina L. Randall and Jane Oliaro. DOCK8 Drives Src-Dependent NK Cell Effector Function. J Immunol (September 2017) 199 (6) 2118-2127

Tangye SG, Pelham S, Deenick EK, Ma CS. Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies. Journal of Immun (September 2017) 199:1949-1958

Tangye SG. Pathogenic CD4+ T cells regulating B-cell differentiation in autoimmunity: not exactly Tfh cells. Immunol Cell Biol. (May 2017) 95(5):419-421

Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL, Smogorzewska A, Jouanguy E. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. (May 2017) 1;127(5):1991-2006

Phan TG, Tangye SG. Memory B cells: total recall. Curr Opin Immunol. (April 2017) 45:132-140

Tangye SG, Palendira U, Edwards ES. Human immunity against EBV-lessons from the clinic. J Exp Med. (February 2017) 214(2):269-283

Abolhassani H, Edwards ES, Ikinciogullari A, Jing H, Borte S, Buggert M, Du L, Matsuda-Lennikov M, Romano R, Caridha R, Bade S, Zhang Y, Frederiksen J, Fang M, Bal SK, Haskologlu S, Dogu F, Tacyildiz N, Matthews HF, McElwee JJ, Gostick E, Price DA, Palendira U, Aghamohammadi A, Boisson B, Rezaei N, Karlsson AC, Lenardo MJ, Casanova JL, Hammarström L, Tangye SG, Su HC, Pan-Hammarström Q. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. J Exp Med. (January 2017) 214(1):91-106.

SG Tangye. Genetic cause of immune dysregulation - one gene or two? J Clin Invest (November 2016) 126:4065-4067

A Kane, A Lau, R Brink, SG Tangye, EK Deenick. B-cell specific STAT3-deficiency: insight into the molecular basis of Autosomal Dominant Hyper IgE Syndrome. J Allergy Clin Immunol (November 2016) 138:1455-1458

AP Meli, G Fontés, DT Avery, SA Leddon, M Tam, M Elliott, A Ballesteros-Tato, J Miller, MM Stevenson, DJ Fowell, SG Tangye, IL King. The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance. Immunity (October 2016) 45:831-846

S Pelham, H Lenthall, EK Deenick, SG Tangye. Elucidating the effects of disease-1 causing mutations on STAT3 function in autosomal dominant hyper-IgE syndrome. J Allergy Clin Immunol (October 2016) 138:1210-1213

Wang Y, Ma CS, Ling Y, Bousfiha A, Camcioglu Y, Jacquot S, Payne K, Crestani E, Roncagalli R, Belkadi A, Kerner G, Lorenzo L, Deswarte D, Chrabieh M, Patin E, Vincent QB, Müller‑Fleckenstein I, Fleckenstein B, Ailal F, Quintana‑Murci L, Fraitag S, Alyanakian MA, Leruez‑Ville M, Capucine P, Puel A, Bustamante J, Boisson‑Dupuis S, Malissen M, Malissen B, Abel L, Hovnanian A, Notarangelo LD, Jouanguy E, Tangye SG, Beziat V, Casanova JL.  Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLT PR mutations. J Exp Med (September 2016) 213:2415-2435

C Ma, SG Tangye. Immunology: Cytotoxic T cells that escape exhaustion.  Nature (September 2016) 537: 312-314

HG Woon, A Braun, JJ Li, C Smith, J Edwards, F Sierro, CG Feng, R Khanna, A Bell, FR Carbone, SG Tangye, AB Rickinson, T Gebhardt, WJ Britton, UI Palendira. IL-15 and TGF-b potentiate the selective retention and strategic positioning of Epstein-Barr virus-specific resident memory CD8+ T cells within human lymphoid tissues. PLoS Pathog (August 2016) 10:1371

J Jurczyluk, MA Munoz, OP Skinner, RC Chai, N Ali, U Palendira, JM Quinn, A Preston, SG Tangye, AJ Brown, E Argent,  JB Ziegler, S Mehr, MJ Rogers. Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases. Immun Cell Biology (July 2016) 94:994-999

CS Ma, N Wong, G Rao, DT Avery, J Torpy, P O’Young, EK Deenick, J Bustamante, S Boisson-Dupuis, A Puel, S Okada, M Kobayashi, M Elliott, S Sebnem Kilic, J El Baghdadi, Y Minegishi, A Bousfiha, P Hsu, DE Campbell, MO Stormon, M Wong, S Adelstein, DA Fulcher, MC Cook, P Stepensky, K Boztug, R Beier, A Ikincioğullari, JB Ziegler, P Gray, C Picard, B Grimbacher, K Warnatz, SM Holland, G Uzel, JL Casanova, SG Tangye.  Unique and shared signaling pathways co-operate to regulate the differentiation of human CD4+ T cells into distinct effector subsets. J Exp Med (July 2016) 10.1084

V Bryant, SG Tangye. The Expanding Spectrum of NFkB1 Deficiency. J Clin Immunol (June 2016) 36:531-532 

SG Tangye, R Brink, CC Goodnow. TG Phan. 2015. Snapshot: Interactions between B cells and T cells. Cell (in press 13 August 2015)  162:926

C Ma, N Wong, G Rao, D Avery, J Torpy, J Bustamante, J Okada, J Stoddard, EK Deenick, S Pelham, S Boisson-Dupuis, A Puel, M Kobayashi, P Arkwright, SS Kilic, J El Baghdadi, S Nonoyama, Y Minegishi, SA Mahdaviani, D Mansouri, A Bousfiha, M French, P Hsu, D Campbell, M Stormon, M Wong, S Adelstein, J Smart, D Fulcher, M Cook, TG Phan, P Stepensky, K Boztug, A Ikincioğullari, R Beier, J Ziegler, P Gray, C Picard, B Grimbacher, K Warnatz, S Holland, JL Casanova, G Uzel, SG Tangye. 2015. Monogenic mutations differentially impact the quantity and quality of T follicular helper cells inhuman primary immunodeficiencies. J Allergy Clin Immunol (Published Online July 8th 2015) 

S Okada, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson L, Marzouqa H, Shamma J, Gonzalez M, Martinez-Baricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Lindestam Arlehamn CS, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay J-P, Moshous D, Hambleton S, Latour S, Arkwright P, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL. Impairment of IL-17 immunity to Candida and IFN-g immunity to Mycobacterium in humans with inherited RORgT deficiency. Science (published online 10th July 2015)

RP Wilson, ML Ives, G Rao, A Lau, K Payne, M Kobayashi, PD Arkwright, J Peake, M Wong, S Adelstein, JM Smart, MA French, DA Fulcher, C Picard, J Bustamante, SBoisson-Dupuis, P Gray, P Stepensky, K Warnatz, AF Freeman, J Rossjohn, J McCluskey, SM Holland, JL Casanova, G Uze,  C Ma, SG Tangye, EK Deenick. 2015. STAT3 is a critical cell intrinsic regulator of human unconventional T cell numbers and function. J Exp Med (May 2015) 212: 855-864

SG Tangye. 2015. Advances is IL-21 biology enchancing our understanding of human disease. Curr Opin Immunol (April 2015). 34: 107-115

SG Tangye. 2014. T cells require DOCK8 for flexibility and function. J Exp Med (December 2014).  211: 2482-2483

CS Ma  & SG Tangye. 2014. Human T follicular helper cells in primary immunodeficiencies. Curr Opin Pediatr (November 2014). 26: 720-726

SG Tangye. 2014. XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP. J Clin Immunol (September 2014). 34: 772-779

SG Tangye. 2014 The right "Job" for STAT3 mutant mice! Blood (May 2014). 123: 2907-2909

L Moens  & SG Tangye. 2014. Cytokine-mediated regulation of plasma cell generation: IL-21 takes centre stage. Frontiers in Immunology (February 2014). 5: 1-13

EK Deenick, DT Avery, A Chan, LJ Berglund, ML Ives, L Moens, JL Stoddard, J Bustamante, S Boisson-Dupuis, M Tsumura, M Kobayashi, PD Arkwright, D Averbuch, D Engelhard, K Magdorf, J Roesler, J Peake, M Wong, S Adelstein, S Choo, JM Smart, MA French, DA Fulcher, MC Cook, C Picard, A Durandy, C Klein, SM Holland, G Uzel, JL Casanova, CS Ma, SG Tangye. 2013. Naïve and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells. J Exp Med (published online November 11th 2013)

CL Lucas, H Kuehn, F Zhao, JE Niemela, EK Deenick, U Palendira, DT Avery, L Moens, JL Cannons, M Biancalana, J Stoddard, W Ouyang, DL Frucht, KM Rao, PT Atkinson, A Agharahimi, AA Hussey, LR Folio, KN Olivier, TA Fleisher, S Pittaluga, SM Holland, JI Cohen, JB Oliviera, SG Tangye, PL Schwartzberg, MJ Lenardo, G Uzel. Dominant-Activating, Germline Mutations in Phosphoinositide 3-Kinase p110 Delta Cause Effector T Cell Senescence and a Novel Human Immunodeficiency. Nat Immunol (published online October 28th 2013)

LJ Berglund, DT Avery, CS Ma, L Moens, EK Deenick, J Bustamante, S Boisson-Dupuis, M Wong, S Adelstein, PD Arkwright, R Bacchetta, L Bezrodnik, H Dadi, C Roifman, DA Fulcher, JB Ziegler, JM Smart, M Kobayashi, C Picard, A Durandy, MC Cook, JL Casanova, G Uzel, SG Tangye. IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts. BLOOD (published online October 25th 2013).

M Byun, CS Ma, A Akçay, V Pedergnana, U Palendira, J Myoung, DT Avery, Y Liu, A Abhyankar, L Lorenzo, M Schmidt, H-K Lim, O Cassar, M Migaud, F Rozenberg, N Canpolat, G Aydoğan, B Fleckenstein, J Bustamante, C Picard, A Gessain, E Jouanguy, E Cesarman, M Olivier, P Gros, L Abel, M Croft, SG Tangye, JL Casanova. Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med. 2013; 210:1743-59.

ML Ives, CS Ma, U Palendira, A Chan, J Bustamante, S Boisson-Dupuis, PD Arkwright, D Engelhardt, D Averbuch K Magdorf, J Roesler, J Peake, M Wong, S Adelstein, S Choo, JM Smart, MA French, DA Fulcher, MC Cook, M Tsumura, M Kobayashi, G Uzel, JL Casanova, SG Tangye*, EK Deenick* (*equal contribution). STAT3 mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T cell memory formation and acquisition of cytotoxic machinery. J Allergy Clin Immunol 2013; 132:400-411.e9.

SG Tangye, CS Ma, R Brink, EK Deenick. The good, the bad and the ugly - Tfh cells in human health and disease. Nat Rev Immunol 2013; 13:412-426.

CS Ma, DT Avery, A Chan, M Batten, J Bustamante, S Boisson-Dupuis, PD Arkwright, AY Kreins, D Averbuch, D Engelhardt, J Roesler, K Magdorf, SS Kilic, Y Minegishi, S Nonoyama, MA French, S Choo, JM Smart, J Peake, M Wong, P Gray, MC Cook, DA Fulcher, JL Casanova, EK Deenick, SG Tangye. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. BLOOD. 2012;119:3997-4008.

U Palendira, C Low, AI Bell, CS Ma, RJ Abbott, TG Phan, DS Riminton, S Choo, JM Smart, V Lougaris, S Giliani, RH Buckley, B Grimbacher, F Alvaro, A Klion, KE Nichols, S Adelstein, AB Rickinson, SG Tangye. Expansion of somatically reverted memory CD8+ T cells in X-linked lymphoproliferative disease is due to selective pressure from Epstein Barr virus. J Exp Med. 2012; 209:913-924

CS Ma, EK Deenick, M Batten, SG Tangye. The origins, function and regulation of T follicular helper cells. J Exp Med 2012; 209:1241-1253.

KL Randall*, SS-Y Chan*, CS Ma*, I Fung*, Y Mei, M Yabas, A Tan, PD Arkwright, W Al Suwairi, S Oswaldo Lugo Reyes, MA Yamazaki-Nakashimada, M de la Luz Garcia-Cruz, JM Smart, C Picard, S Okada, E Jouanguy, J-L Casanova, RJ Cornall, S Russell, J Oliaro*, SG Tangye*, EM Bertram*, CC Goodnow* (*equal contribution). DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med 2011; 208:2305-2320.

U Palendira, C Low, A Chan, AD Hislop, E Ho, TG Phan, EK Deenick, MC Cook, DS Riminton, S Choo, R Loh, C Booth, HB Gaspar, A Moretta, R Khanna, AB Rickinson, SG Tangye. Molecular pathogenesis of EBV infection as revealed by analysis of XLP carriers with heterozygous expression of SAP. PLoS Biol 2011; 9:e1001187.

M Recher*, LJ Berglund*, DT Avery, MJ Cowan, AR Gennery, J Smart, J Peake, M Wong, S-Yun Pai, S Baxi, JE Walter, U Palendira, GA Tangye, M Rice, S Brothers, W Al-Herz, H Oettgen, H Eibel, JM Puck, F Cattaneo, JB Ziegler, S Giliani, SG Tangye*, LD Notarangelo* (*equal contribution). IL-21 is the primary common gamma chain-binding cytokine required for human B-cell differentiation in vivo. BLOOD 2011; 118:6824-6835.

SG Tangye. Staying alive – survival factors for B cells and plasma cells. Trends Immunol. 2011; 32:595-602.

EK Deenick, A Chan, CS Ma, D Gatto, PL Schwartzberg, R Brink*, SG Tangye* (*equal contribution). Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 2010; 33:241-253.

DT Avery, EK Deenick, CS Ma, S Suryani, N Simpson, GY Chew, TD Chan, U Palendira, J Bustamante, S Boisson-Dupuis, S Choo, KE Bleasel, J Peake, C King, MA French, D Engelhard, S Al-Hajjar, S Al-Muhsen, K Magdorf, J Roesler, PD Arkwright, P Hissaria, DS Riminton, M Wong, R Brink, DA Fulcher, J-L Casanova, MC Cook, and SG Tangye. B-cell intrinsic signalling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 2010; 207:155-171.

S Suryani, DA Fulcher, B Santner-Nanan, R Nanan, M Wong, PJ Shaw, J Gibson, A Williams, and SG Tangye. Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. BLOOD 2010; 115:519-529.

CS Ma, S Suryani, DT Avery, A Chan, R Nanan, B Nanan, EK Deenick, SG Tangye. Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL-12. Immunol Cell Biol. 2009; 87:590-600

CS Ma, GYJ Chew, N Simpson, A Priyadarshi, M Wong, B Grimbacher, DA Fulcher, SG Tangye*, MC Cook* (equal contribution). Hyper IgE syndrome due to mutations in STAT3 represents a Th17 deficiency. J Exp Med 2008; 205:1551-1557.

DT Avery, VL Bryant, CS Ma, R de Waal Malefyt, and SG Tangye. IL-21-induced isotype switching to IgG and IgA by human naïve B cells is differentially regulated by IL-4. J Immunol 2008; 181:1767-1779.

VL Bryant, CS Ma, DT Avery, Y Li, KL Good, LM Corcoran, R de Waal Malefyt and SG Tangye. Cytokine-mediated regulation of human B-cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol 2007; 179:8180-8190.

KL Good and SG Tangye. Decreased expression of Krüppel-like factors in memory B cells induces the accelerated response typical of secondary antibody responses. Proc Natl Acad Sci USA. 2007; 104:13420-13425.

CS Ma, KE Nichols and SG Tangye. Regulation of cellular and humoral immune responses by the SLAM and SAP Families of molecules. Annu. Rev. Immunol. 2007; 25:337-379.

CS Ma, S Pittaluga, DT Avery, NJ Hare, AD Klion, I Maric, KE Nichols and SG Tangye. Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest. 2006; 116:322-333.

AK Cuss, DT Avery, JL Cannons, LJ Yu, KE Nichols, PJ Shaw, and SG Tangye. Expansion of functionally immature transitional B cells is associated with human immunodeficient states characterised by impaired humoral immunity. J Immunol 2006; 176:1506-1516.

SG Tangye, VL Bryant, AK Cuss and KL Good. BAFF, APRIL and human B cell disorders. Sem Immunol. 2006; 118:305-317.

CS Ma, NJ Hare, KE Nichols, L Dupre, G Andolfi, MG Roncarolo, S Adelstein, PD Hodgkin, and SG Tangye. Impaired humoral immunity in XLP is associated with defective IL-10 production by CD4+ T cells. J. Clin. Invest. 2005; 115:1049-1059.

DT Avery, JI Ellyard, F Mackay, LM Corcoran, PD Hodgkin, and SG Tangye. Increased expression of CD27 on activated human memory B cells correlates with commitment to the plasma cell lineage. J. Immunol. 2005; 174:4034-4042.

JI Ellyard, DT Avery, TG Phan, NJ Hare, PD Hodgkin and SG Tangye. Ag-selected Ig-secreting cells persist in human spleen as well as bone marrow. Blood. 2004; 103:3805-3812.

DT Avery, SL Kalled, JI Ellyard, C Ambrose, SA Bixler, M Thien, R Brink, F Mackay, PD Hodgkin and SG Tangye. BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J. Clin. Invest 2003; 112:286-297.


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