Emily undertook her PhD in the T-cell Crossreactivity laboratory at Cardiff University, under the supervision of Prof Linda Wooldridge. Here she studied the impact of peptide modification on the priming of antigen-specific CD8+ T cell responses quantity and quality. Following her PhD she moved to Australia to undertake a postdoctoral position in the lab of Prof Rajiv Khanna at the QIMR Berghofer Medical Research Institute. There she investigated the functional and transcriptional profile of virus-specific CD4+ T-cells.
In 2014, she joined the Garvan Institute as a postdoc in the Immunology and Immunodeficiency lab. Here she is continuing her interest in dissecting the phenotypic characteristics of T-cells, using primary human cells to delineate the phenotypic profile of virus-specific T-cells in immunodeficiency, as well as the signals that facilitate these altered profiles.
Awards and Honours
2013 - Australasian Society of Immunology (ASI) Travel Award
2007-2011 – Infection, Immunity & Inflammation interdisciplinary immunological research group (i3-IRG) - PhD Studentship, Cardiff University
2007 - BSc (Applied Biomedical Science); Hons-First Class, UWIC - UK
Tangye SG;Palendira U;Edwards ES J, (2017). Human immunity against EBV-lessons from the clinic. J Exp Med 214, 269 - 283.
Abolhassani H;Edwards ES J;Ikinciogullari A;Jing H;Borte S;Buggert M;Du L;Matsuda-Lennikov M;Romano R;Caridha R;Bade S;Zhang Y;Frederiksen J;Fang M;Bal SK;Haskologlu S;Dogu F;Tacyildiz N;Matthews HF;McElwee JJ;Gostick E;Price DA;Palendira U;Aghamohammadi A;Boisson B;Rezaei N;Karlsson AC;Lenardo MJ;Casanova JL;Hammarström L;Tangye SG;Su HC;Pan-Hammarström Q, (2017). Combined immunodeficiency and Epstein-Barr virus- induced B cell malignancy in humans with inherited CD70 deficiency. J Exp Med 214, 91 - 106.
Edwards, E.S., Smith, C., and Khanna, R. (2014). Phenotypic and transcriptional profile correlates with functional plasticity of antigen-specific CD4+ T-cells. Immunol and Cell Bio 92, 181-190.
Ekeruche-Makinde, J., Clement, M., Cole, D.K., Edwards, E.S.J., Ladell, K., Miles, J.J., Mathews, K.K., Fuller, A., Lloyd, K.A., Madura, F., Dolton GM;Pentier J;Lissina A;Gostick E;Baxter TK;Baker BM;Rizkallah PJ;Price DA;Wooldridge L;Sewell AK, (2012). T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. J Biol Chem 287, 37269-37281.
Clement, M., Ladell, K., Ekeruche-Makinde, J., Miles, J.J., Edwards, E.S.J., Dolton, G., Williams, T., Chauenburg, A.J.A., Cole, D.K., Lauder, S.N., Gallimore AM;Godkin AJ;Burrows SR;Price DA;Sewell AK;Wooldridge L, (2011). Anti-CD8 Antibodies Can Trigger CD8+ T Cell effector function in the absence of TCR Engagement and Improve Peptide Recognition. J Immunol 187, 654-663.
Cole, D.K., Edwards, E.S., Wynn, K.K., Clement, M., Miles, J.J., Ladell, K., Ekeruche, J., Gostick, E., Adams, K.J., Skowera, A., Peakman M;Wooldridge L;Price DA;Sewell AK, (2010). Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. J Immunol 185, 2600-2610.
Wooldridge, L., Clement, M., Lissina, A., Edwards, E.S.J., Ladella, K., Ekeruche, J., Hewitt, R.E., Laugel, B., Gostick, E., Cole, D.K., Debets R;Berrevoets C;Miles JJ;Burrows SR;Price DA;Sewell AK, (2010). MHC class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. J Immunol 184, 3357-3366.
Tarbe, M., Azcune, I., Balentova, E., Miles, J.J., Edwards, E., Miles, K.M., Do, P., Baker, B., Sewell, A., Aizpurua, J., Douat-Casassus C;Quideau S, (2010).Design, synthesis and evaluation of b-lactam antigenic peptide hybrids; unusual opening of the b-lactam ring in acidic media. Org Biomol Chem 8, 5345-5353.
Lissina, A., Ladell, K., Skowera, A., Clement, M., Edwards, E., Seggewiss, R., van den Berg, H.A., Gostick, E., Gallagher, K., Jones, E., Melenhorst JJ;Godkin AJ;Peakman M;Price DA;Sewell AK;Wooldridge L, (2008). Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. J Immunol Methods 340, 11-24.