Innate and Tumour Immunology
One of the hallmarks of the immune system is the ability of immune cells to migrate long distances to respond to invading pathogens in any part of the body. We use a combination of in vivo imaging and transgenic mouse systems to study immune cell migration. We use models of melanoma, lung and breast cancer.
Our research focuses on two main areas:
- Innate immune responses: Our Lab studies migration of innate immune cells and especially an immune cell called the neutrophil in different inflammatory settings including bacterial infections and sterile injuries.
- Tumour immunology: Our Lab also investigates migration of immune cells in response to tumours. Immune responses to tumours involve complex interplay between various cells of the immune system and the tumour microenvironment which modifies normal functions of immune cells. We have asked the following questions: Which immune cell can emigrate from the tumour? Where do they migrate and what functions do they perform outside of primary tumours? We are using photoconvertible transgenic mice to ‘tag’ these immune cells inside the tumours and follow their migration.