Dr Tatyana Chtanova
Senior Research Officer
Tatyana graduated from the University of New South Wales with first class Honours in Biochemistry and Molecular Genetics in 1999. She was awarded her PhD in 2005 from UNSW for her thesis work on the identification of specific gene expression signatures for multiple T cell subsets, performed at the Garvan Institute under the supervision of Professor Charles Mackay.
Following her PhD, Tatyana obtained the highly competitive Human Frontier Science Program fellowship to train at University of California, Berkeley in the laboratory of Professor Ellen Robey. There she gained expertise in in vivo two-photon microscopy and used it to characterise, for the first time, neutrophil dynamics in vivo, and to identify a novel mechanism of immune evasion by pathogens via CD8 T cells.
Tatyana relocated to the Garvan Institute in May 2009 to establish her research laboratory within the Division of Immunology. Tatyana’s main research interest is immune cell migration in normal immune responses as well as in cancer. Tatyana’s group utilises a range of innovative techniques to analyse cell migration including in vivo two-photon microscopy as well as photoconvertible transgenic mouse systems.
In the NewsWinners of Garvan’s Childcare Travel Awards announced - May 12, 2016
NHMRC funding success for Garvan researchers - Nov 09, 2015
Frontline immune cells can travel for help - May 14, 2015
Memory immune cells that screen intruders as they enter lymph nodes - Apr 01, 2015
Garvan receives $15.5 million in NHMRC funding round - Oct 25, 2013
Awards and Honours
2011-2013 - Human Frontier Science Program Career Development Award
2009-2012 - Cancer Institute NSW Career Development Award
2008 - Best Short Talk Award at FASEB Biology of the Immune System Summer conference
2005-2008 - Human Frontier Science Program Long-Term Fellowship
2001-2004 - University Postgraduate Research Scholarship –UNSW, Sydney, Australia
2004 - Keystone Symposia Travel Scholarship
2001-2003 - Australian Co-operative Research Center for Asthma scholarship
2001 - Australian Asthma Foundation Scholarship
1999 - BSc (Hons) - School of Biochemistry and Molecular Genetics, University of New South Wales - Australia
Suan D, Nguyen A, Moran I, Bourne K, Hermes J, Hampton HR, Tomura M, Miwa Y, Kelleher AD, Kaplan W, Deenick EK, Tangye SG, Brink R, Chtanova T, Phan TG. T follicular helper celles have distinct modes of migration and molecular signatures in naive and memory immune responses. Immunity 2015; 42(4):704-18
Hampton HR, Bailey J, Brink R, Chtanova T. Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes. Nat Commun 2015; 6:7139.
Suan D, Hampton HR, Tomura M, Kanagawa O, Chtanova T, Phan T. Optimizing fluorescence excitation and detection for intravital two-photon microscopy. Methods Cell Biol 2013; 113, 311-323.
Chtanova, T. et al. Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice. J Biophotonics, 2012; Nov 26. doi: 10.1002/jbio.201200175
Phan TG and Chtanova T. Lymphocyte activation - Border patrol: SCS macrophages activate iNKT cells too. Immunology and Cell Biology. 2010; 88(6):619-21.
Chtanova T, Han S-J, Schaeffer M, van Dooren G, Herzmark P, Striepen B, and Robey EA. Dynamics of T cell, antigen presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity 2009; 31(2):342-55.
Schaeffer M, Han S-J, Chtanova T, van Dooren G, Herzmark P, Chen Y, Roysam B, Striepen B, and Robey EA. 2009. Dynamic imaging of T cell - parasite interactions in the brains of mice chronically infected with Toxoplasma gondi. J Immunol. 2009; 182:6379-93.
Chtanova T, Schaeffer M, Han S-J, van Dooren G, Striepen B, Herzmark P, Camfield K, Nollmann M, Aaron H, and Robey EA. Dynamics of neutrophil migration in lymph nodes during Toxoplasma gondii infection. Immunity 2008; 29:487-96.
Ladi E, Schwickert TA, Chtanova T, Chen Y, Herzmark P, Yin X, Aaron H, Chan SW, Lipp M, Roysam B, Robey EA. Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex. J Immunol 2008; 181:7014-23.
Liu SM, Xavier R, Good KL, Chtanova T, Newton R, Sisavanh M, Zimmer S, Deng C, Silva DG, Frost MJ, Tangye SG, Rolph MS, Mackay CR. Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes. J Allergy Clin Immunol. 2006; 118(2):496-503.
Ladi E, Chtanova T, Yin X, Robey EA. 2006. Thymic microenvironments for T cell differentiation and selection. Nat Immunol. 7(4):338. Review.
Yin X, Ladi E, Chtanova T, Robey EA. Thymocyte motility: mutants, movies and migration patterns. Curr Opin Immunol. 2006; 18(2):191-7. Review.
Chtanova T, Newton R, Liu SM, Weininger L, Young TR, Silva DG, Bertoni F, Rinaldi A, Chappaz S, Sallusto F, Rolph MS, Mackay CR. Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets. J Immunol. 2005; 175:7837-47.
Chtanova T, Tangye SG, Newton RA, Frank N, Hodge MR, Rolph MS, Mackay CR. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004; 173:68-78.
Ng LG, Sutherland APR, Newton RA, Qian F, Cachero TG, Scott M, Thompson JS, Wheway J, Chtanova T, Xin C, Groom J, Tangye SG,Kalled SL, Mackay F, Mackay CR. BAFF-R is the principal BAFF receptor facilitating BAFF co-stimulation of B and T cells. J Immunol 2004; 173:807-17.
Chtanova T, and Mackay CR. T cell effector subsets: extending the Th1/Th2 paradigm. Adv Immunol 2001; 78:233-66. Review.
Chtanova T, Kemp RA, Sutherland AP, Ronchese F, Mackay CR. Gene microarrays reveal extensive differential gene expression in both CD4+ and CD8+ type 1 and type 2 T cells. J Immunol 2001; 167:3057-63.